Genomic and proteomic biomarker discovery in neurological disease

Ri Lee H. Robeson, Andrew M. Siegel, Travis Dunckley

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Technology for high-throughout scanning of the human genome and its encoded proteins have rapidly developed to allow systematic analyses of human disease. Application of these technologies is becoming an increasingly effective approach for identifying the biological basis of genetically complex neurological diseases. This review will highlight significant findings resulting from the use of a multitude of genomic and proteomic technologies toward biomarker discovery in neurological disorders. Through substantial discoveries have been made there is clearly significant promise and potential remaining to be fully realized through-increasing use of and further development of omic technologies.

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalBiomarker Insights
Volume2008
Issue number3
StatePublished - Feb 27 2008
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Biomarker
  • Gene expression profiling
  • Genomics
  • Neurodegeneration
  • Neurological disease
  • Parkinson's disease
  • Proteomics
  • SNP
  • aCGH

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Biochemistry, medical

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