Genetically modified rodent models: A new generation of translational cognitive science

Salvatore Oddo, Masashi Kitazawa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The brain is the key organ that differentiates humans from each other and from other animals; it stores personal experiences and knowledge in the form of memories, integrates all external information, and controls fundamental functions for survival. The underlying molecular mechanisms of learning and memory, and maintaining such high plasticity and flexibility in the brain, have remained long-lasting mysteries in the field of neuroscience. This chapter primarily focuses on the role of neurons and signal transduction pathways within the neuronal cells in learning and memory, and details the procedures used for generating genetically modified rodents. Also discussed is the application of knockout and knock-in models to understand the underlying molecular mechanisms of learning and memory, as well as the advantages and limitations of their use.

Original languageEnglish (US)
Title of host publicationThe Maze Book
Subtitle of host publicationTheories, Practice, and Protocols for Testing Rodent Cognition
PublisherSpringer New York
Pages259-283
Number of pages25
ISBN (Electronic)9781493921591
ISBN (Print)9781493921584
DOIs
StatePublished - Mar 10 2015

Keywords

  • Animal model, transgenic
  • Behavior
  • Brain
  • Gene modification
  • Genetic
  • Knock-in
  • Knockout
  • Learning
  • Mutation
  • Pathology
  • Signal transduction

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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  • Cite this

    Oddo, S., & Kitazawa, M. (2015). Genetically modified rodent models: A new generation of translational cognitive science. In The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition (pp. 259-283). Springer New York. https://doi.org/10.1007/978-1-4939-2159-1_9