Genetic variation of major histocompatibility complex and microsatellite loci

A comparison in bighorn sheep

Walter M. Boyce, Philip W. Hedrick, Noelle E. Muggli-Cockett, Steven Kalinowski, Maria Cecilia T Penedo, Rob R. Ramey

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Examining and comparing genetic variation for major histocompatibility complex (MHC) and microsatellite (MS) loci in the same individuals provides an opportunity to understand the forces influencing genetic variation. We examined five MHC and three MS loci in 235 bighorn sheep (Ovis canadensis) from 14 populations and found that both types of loci were highly variable and were in Hardy-Weinberg proportions. Mean F(ST) values for both markers were very similar and MHC and MS genetic variability was predominantly distributed within rather than among populations. However, analyses of genetic distances and tree topologies revealed different spatial patterns of variation for the two types of loci. Collectively, these results indicated that neutral forces substantially influenced MS and MHC variation, and they provided limited evidence for selection acting on the MHC.

Original languageEnglish (US)
Pages (from-to)421-433
Number of pages13
JournalGenetics
Volume145
Issue number2
StatePublished - Feb 1997

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Bighorn Sheep
Major Histocompatibility Complex
Microsatellite Repeats
Population

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Boyce, W. M., Hedrick, P. W., Muggli-Cockett, N. E., Kalinowski, S., Penedo, M. C. T., & Ramey, R. R. (1997). Genetic variation of major histocompatibility complex and microsatellite loci: A comparison in bighorn sheep. Genetics, 145(2), 421-433.

Genetic variation of major histocompatibility complex and microsatellite loci : A comparison in bighorn sheep. / Boyce, Walter M.; Hedrick, Philip W.; Muggli-Cockett, Noelle E.; Kalinowski, Steven; Penedo, Maria Cecilia T; Ramey, Rob R.

In: Genetics, Vol. 145, No. 2, 02.1997, p. 421-433.

Research output: Contribution to journalArticle

Boyce, WM, Hedrick, PW, Muggli-Cockett, NE, Kalinowski, S, Penedo, MCT & Ramey, RR 1997, 'Genetic variation of major histocompatibility complex and microsatellite loci: A comparison in bighorn sheep', Genetics, vol. 145, no. 2, pp. 421-433.
Boyce WM, Hedrick PW, Muggli-Cockett NE, Kalinowski S, Penedo MCT, Ramey RR. Genetic variation of major histocompatibility complex and microsatellite loci: A comparison in bighorn sheep. Genetics. 1997 Feb;145(2):421-433.
Boyce, Walter M. ; Hedrick, Philip W. ; Muggli-Cockett, Noelle E. ; Kalinowski, Steven ; Penedo, Maria Cecilia T ; Ramey, Rob R. / Genetic variation of major histocompatibility complex and microsatellite loci : A comparison in bighorn sheep. In: Genetics. 1997 ; Vol. 145, No. 2. pp. 421-433.
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