TY - JOUR
T1 - Genetic variation of major histocompatibility complex and microsatellite loci
T2 - A comparison in bighorn sheep
AU - Boyce, Walter M.
AU - Hedrick, Philip W.
AU - Muggli-Cockett, Noelle E.
AU - Kalinowski, Steven
AU - Penedo, Maria Cecilia T
AU - Ramey, Rob R.
PY - 1997/2/1
Y1 - 1997/2/1
N2 - Examining and comparing genetic variation for major histocompatibility complex (MHC) and microsatellite (MS) loci in the same individuals provides an opportunity to understand the forces influencing genetic variation. We examined five MHC and three MS loci in 235 bighorn sheep (Ovis canadensis) from 14 populations and found that both types of loci were highly variable and were in Hardy-Weinberg proportions. Mean F(ST) values for both markers were very similar and MHC and MS genetic variability was predominantly distributed within rather than among populations. However, analyses of genetic distances and tree topologies revealed different spatial patterns of variation for the two types of loci. Collectively, these results indicated that neutral forces substantially influenced MS and MHC variation, and they provided limited evidence for selection acting on the MHC.
AB - Examining and comparing genetic variation for major histocompatibility complex (MHC) and microsatellite (MS) loci in the same individuals provides an opportunity to understand the forces influencing genetic variation. We examined five MHC and three MS loci in 235 bighorn sheep (Ovis canadensis) from 14 populations and found that both types of loci were highly variable and were in Hardy-Weinberg proportions. Mean F(ST) values for both markers were very similar and MHC and MS genetic variability was predominantly distributed within rather than among populations. However, analyses of genetic distances and tree topologies revealed different spatial patterns of variation for the two types of loci. Collectively, these results indicated that neutral forces substantially influenced MS and MHC variation, and they provided limited evidence for selection acting on the MHC.
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M3 - Review article
C2 - 9071595
AN - SCOPUS:0031014290
SN - 0016-6731
VL - 145
SP - 421
EP - 433
JO - Genetics
JF - Genetics
IS - 2
ER -