TY - JOUR
T1 - Genetic variation and population structure in Native Americans
AU - Wang, Sijia
AU - Lewis, Cecil M.
AU - Jakobsson, Mattias
AU - Ramachandran, Sohini
AU - Ray, Nicolas
AU - Bedoya, Gabriel
AU - Rojas, Winston
AU - Parra, Maria V.
AU - Molina, Julio A.
AU - Gallo, Carla
AU - Mazzotti, Guido
AU - Poletti, Giovanni
AU - Hill, Kim
AU - Hurtado, Ana M.
AU - Labuda, Damian
AU - Klitz, William
AU - Barrantes, Ramiro
AU - Bortolini, Maria Catira
AU - Salzano, Francisco M.
AU - Petzl-Erler, Maria Luiza
AU - Tsuneto, Luiza T.
AU - Llop, Elena
AU - Rothhammer, Francisco
AU - Excoffier, Laurent
AU - Feldman, Marcus W.
AU - Rosenberg, Noah A.
AU - Ruiz-Linares, Andrés
PY - 2007/11
Y1 - 2007/11
N2 - We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians - signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas.
AB - We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians - signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas.
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U2 - 10.1371/journal.pgen.0030185
DO - 10.1371/journal.pgen.0030185
M3 - Article
C2 - 18039031
AN - SCOPUS:37349025758
SN - 1553-7390
VL - 3
SP - 2049
EP - 2067
JO - PLoS genetics
JF - PLoS genetics
IS - 11
ER -