Genetic to genomic vaccination

Stephen Albert Johnston; Michael A. Barry

doi:10.1016/S0264-410X(96)00276-9

Genetic to genomic vaccination

Stephen Albert Johnston, Michael A. Barry

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Our development of genetic immunization (unfortunately named 'DNA'- immunization at times) seems to have great promise as a vaccine delivery system. However, one is still left with the often formidable problem of discovering what gene of the pathogen to include in the genetic immunization vector. This is particularly a problem with pathogens with large genomes such as bacteria and parasites. We have developed a potential solution to this problem termed 'expression library immunization'. It involves using expression libraries in genetic immunization vectors to basically strip down the genome into protective genes. It may offer a systematic, unbiased approach to discover vaccine candidates.

Original language	English (US)
Pages (from-to)	808-809
Number of pages	2
Journal	Vaccine
Volume	15
Issue number	8
DOIs	https://doi.org/10.1016/S0264-410X(96)00276-9
State	Published - Jun 1997
Externally published	Yes

Keywords

ELI
Expression library
Genome

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(96)00276-9

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AB - Our development of genetic immunization (unfortunately named 'DNA'- immunization at times) seems to have great promise as a vaccine delivery system. However, one is still left with the often formidable problem of discovering what gene of the pathogen to include in the genetic immunization vector. This is particularly a problem with pathogens with large genomes such as bacteria and parasites. We have developed a potential solution to this problem termed 'expression library immunization'. It involves using expression libraries in genetic immunization vectors to basically strip down the genome into protective genes. It may offer a systematic, unbiased approach to discover vaccine candidates.

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KW - Expression library

KW - Genome

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Genetic to genomic vaccination

Abstract

Keywords

ASJC Scopus subject areas

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