Genetic testing for Alzheimer's disease and its impact on insurance purchasing behavior

Cathleen D. Zick, Charles J. Mathews, J. Scott Roberts, Robert Cook-Deegan, Robert J. Pokorski, Robert C. Green

Research output: Contribution to journalArticle

84 Scopus citations


New genetic tests for adult-onset diseases raise concerns about possible adverse selection in insurance markets. To test for this behavior, we followed 148 cognitively normal people participating in a randomized clinical trial of genetic testing for Alzheimer's disease for one year after risk assessment and Apolipoprotein E (APOE) genotype disclosure. Although no significant differences were found in health, life, or disability insurance purchases, those who tested positive were 5.76 times more likely to have altered their long-term care insurance than those who did not receive APOE genotype disclosure. If genetic testing for Alzheimer's risk assessment becomes common, it could trigger adverse selection in long-term care insurance.

Original languageEnglish (US)
Pages (from-to)483-490
Number of pages8
JournalHealth Affairs
Issue number2
StatePublished - Mar 1 2005


ASJC Scopus subject areas

  • Health Policy

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