@article{6477ddc901d942528d46549534525cad,
title = "Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat",
abstract = "The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-characterized model for primary hypertension in humans. High blood pressure in SHRSP shows polygenic inheritance, but none of the loci responsible have previously been identified. To locate genes controlling this quantitative trait, we mapped a large collection of DNA polymorphisms in a cross between SHRSP and the normotensive WKY strain. Here we report strong genetic evidence that a gene, Bp1, having a major effect on blood pressure maps to rat chromosome 10 with a LOD score of 5.10 and is closely linked to the rat gene encoding angiotensin-converting enzyme (ACE), an enzyme that plays a major role in blood pressure homeostasis and is an important target of anti- hypertensive drugs. We also find significant, albeit weaker, linkage to a locus, Bp2, on chromosome 18. We discuss the implications of genetic dissection of quantitative disease-related phenotypes in mammals.",
author = "Jacob, {Joward J.} and Klaus Lindpaintner and Lincoln, {Stephen E.} and Kenro Kusumi and Bunker, {Ruth K.} and Mao, {Yi Pei} and Detlev Ganten and Dzau, {Victor J.} and Lander, {Eric S.}",
note = "Funding Information: We are indebted to William Dietrich for advice and encouragement concerning the generation and typing of simple sequence repeat markers; Hillary Katz for advice and assistance with DNA sequencing; William Dietrich, Giselle Drouin, Peter Groot, Joyce Miller, Rene Pluis, Julie Segre, Jenny Sue Smith, and Alix Weaver for assistance in characterization and typing of some of the genetic markers; and Mark Daly for assistance in automated PCR primer selection. We are especially grateful to Claude and Josiane Szpirer for providing the rat somatic cell hybrid panel that was used for assigning genetic markers to chromosomes. We thank Jim Hudson and Research Genetics for exceptional service in the supply of oligonucleotides. This work was sup ported in part bygrantsfrom the National Institutesof Health (HG00198 to E. S. L.; HL42663 to V. J. D. and E.S.L.; HL35610 and HL35252 to V. J. D.; HL35821-01 to D. G.), the National Science Foundation (DCB-8611317 to E. S. L.), the Markey Foundation (to E. S. L.), and the Deutsche Forschungs Gemeinschaft (SFB 317 to D. G.).",
year = "1991",
month = oct,
day = "4",
doi = "10.1016/0092-8674(91)90584-L",
language = "English (US)",
volume = "67",
pages = "213--224",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",
}