Abstract
To produce an immune reaction against a foreign protein usually requires purification of that protein, which is then injected into an animal. The isolation of enough pure protein is time-consuming and sometimes difficult. Here we report that such a response can also be elicited by introducing the gene encoding a protein directly into the skin of mice. This is achieved using a hand-held form of the biolistic system1-4 which can propel DNA-coated gold micro-projectiles directly into cells in the living animal 3,5,6. Genetic immunization may be time- and labour-saving in producing antibodies and may offer a unique method for vaccination.
Original language | English (US) |
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Pages (from-to) | 152-154 |
Number of pages | 3 |
Journal | Nature |
Volume | 356 |
Issue number | 6365 |
DOIs | |
State | Published - 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- General