Genetic immunization is a simple method for eliciting an immune response

De Chu Tang, Michael DeVit, Stephen Johnston

Research output: Contribution to journalArticle

1227 Citations (Scopus)

Abstract

To produce an immune reaction against a foreign protein usually requires purification of that protein, which is then injected into an animal. The isolation of enough pure protein is time-consuming and sometimes difficult. Here we report that such a response can also be elicited by introducing the gene encoding a protein directly into the skin of mice. This is achieved using a hand-held form of the biolistic system1-4 which can propel DNA-coated gold microprojectiles directly into cells in the living animal3,5,6. Genetic immunization may be time- and labour-saving in producing antibodies and may offer a unique method for vaccination.

Original languageEnglish (US)
Pages (from-to)152-154
Number of pages3
JournalNature
Volume356
Issue number6365
StatePublished - Mar 12 1992
Externally publishedYes

Fingerprint

Immunization
Proteins
Biolistics
Gold
Vaccination
Hand
Skin
Antibodies
DNA
Genes

ASJC Scopus subject areas

  • General

Cite this

Genetic immunization is a simple method for eliciting an immune response. / Tang, De Chu; DeVit, Michael; Johnston, Stephen.

In: Nature, Vol. 356, No. 6365, 12.03.1992, p. 152-154.

Research output: Contribution to journalArticle

Tang, DC, DeVit, M & Johnston, S 1992, 'Genetic immunization is a simple method for eliciting an immune response', Nature, vol. 356, no. 6365, pp. 152-154.
Tang, De Chu ; DeVit, Michael ; Johnston, Stephen. / Genetic immunization is a simple method for eliciting an immune response. In: Nature. 1992 ; Vol. 356, No. 6365. pp. 152-154.
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