Genetic immunization is a simple method for eliciting an immune response

De Chu Tang, Michael Devit, Stephen A. Johnston

Research output: Contribution to journalArticle

1241 Scopus citations

Abstract

To produce an immune reaction against a foreign protein usually requires purification of that protein, which is then injected into an animal. The isolation of enough pure protein is time-consuming and sometimes difficult. Here we report that such a response can also be elicited by introducing the gene encoding a protein directly into the skin of mice. This is achieved using a hand-held form of the biolistic system1-4 which can propel DNA-coated gold micro-projectiles directly into cells in the living animal 3,5,6. Genetic immunization may be time- and labour-saving in producing antibodies and may offer a unique method for vaccination.

Original languageEnglish (US)
Pages (from-to)152-154
Number of pages3
JournalNature
Volume356
Issue number6365
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • General

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