Genetic drift, selection and the evolution of the mutation rate

Michael Lynch, Matthew S. Ackerman, Jean Francois Gout, Hongan Long, Way Sung, W. Kelley Thomas, Patricia L. Foster

Research output: Contribution to journalReview article

124 Citations (Scopus)

Abstract

As one of the few cellular traits that can be quantified across the tree of life, DNA-replication fidelity provides an excellent platform for understanding fundamental evolutionary processes. Furthermore, because mutation is the ultimate source of all genetic variation, clarifying why mutation rates vary is crucial for understanding all areas of biology. A potentially revealing hypothesis for mutation-rate evolution is that natural selection primarily operates to improve replication fidelity, with the ultimate limits to what can be achieved set by the power of random genetic drift. This drift-barrier hypothesis is consistent with comparative measures of mutation rates, provides a simple explanation for the existence of error-prone polymerases and yields a formal counter-argument to the view that selection fine-tunes gene-specific mutation rates.

Original languageEnglish (US)
Pages (from-to)704-714
Number of pages11
JournalNature Reviews Genetics
Volume17
Issue number11
DOIs
StatePublished - Oct 14 2016
Externally publishedYes

Fingerprint

Genetic Drift
Mutation Rate
Genetic Selection
DNA Replication
Mutation
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Lynch, M., Ackerman, M. S., Gout, J. F., Long, H., Sung, W., Thomas, W. K., & Foster, P. L. (2016). Genetic drift, selection and the evolution of the mutation rate. Nature Reviews Genetics, 17(11), 704-714. https://doi.org/10.1038/nrg.2016.104

Genetic drift, selection and the evolution of the mutation rate. / Lynch, Michael; Ackerman, Matthew S.; Gout, Jean Francois; Long, Hongan; Sung, Way; Thomas, W. Kelley; Foster, Patricia L.

In: Nature Reviews Genetics, Vol. 17, No. 11, 14.10.2016, p. 704-714.

Research output: Contribution to journalReview article

Lynch, M, Ackerman, MS, Gout, JF, Long, H, Sung, W, Thomas, WK & Foster, PL 2016, 'Genetic drift, selection and the evolution of the mutation rate', Nature Reviews Genetics, vol. 17, no. 11, pp. 704-714. https://doi.org/10.1038/nrg.2016.104
Lynch M, Ackerman MS, Gout JF, Long H, Sung W, Thomas WK et al. Genetic drift, selection and the evolution of the mutation rate. Nature Reviews Genetics. 2016 Oct 14;17(11):704-714. https://doi.org/10.1038/nrg.2016.104
Lynch, Michael ; Ackerman, Matthew S. ; Gout, Jean Francois ; Long, Hongan ; Sung, Way ; Thomas, W. Kelley ; Foster, Patricia L. / Genetic drift, selection and the evolution of the mutation rate. In: Nature Reviews Genetics. 2016 ; Vol. 17, No. 11. pp. 704-714.
@article{51e085d6fc88426087fb6f27a367e850,
title = "Genetic drift, selection and the evolution of the mutation rate",
abstract = "As one of the few cellular traits that can be quantified across the tree of life, DNA-replication fidelity provides an excellent platform for understanding fundamental evolutionary processes. Furthermore, because mutation is the ultimate source of all genetic variation, clarifying why mutation rates vary is crucial for understanding all areas of biology. A potentially revealing hypothesis for mutation-rate evolution is that natural selection primarily operates to improve replication fidelity, with the ultimate limits to what can be achieved set by the power of random genetic drift. This drift-barrier hypothesis is consistent with comparative measures of mutation rates, provides a simple explanation for the existence of error-prone polymerases and yields a formal counter-argument to the view that selection fine-tunes gene-specific mutation rates.",
author = "Michael Lynch and Ackerman, {Matthew S.} and Gout, {Jean Francois} and Hongan Long and Way Sung and Thomas, {W. Kelley} and Foster, {Patricia L.}",
year = "2016",
month = "10",
day = "14",
doi = "10.1038/nrg.2016.104",
language = "English (US)",
volume = "17",
pages = "704--714",
journal = "Nature Reviews Genetics",
issn = "1471-0056",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - Genetic drift, selection and the evolution of the mutation rate

AU - Lynch, Michael

AU - Ackerman, Matthew S.

AU - Gout, Jean Francois

AU - Long, Hongan

AU - Sung, Way

AU - Thomas, W. Kelley

AU - Foster, Patricia L.

PY - 2016/10/14

Y1 - 2016/10/14

N2 - As one of the few cellular traits that can be quantified across the tree of life, DNA-replication fidelity provides an excellent platform for understanding fundamental evolutionary processes. Furthermore, because mutation is the ultimate source of all genetic variation, clarifying why mutation rates vary is crucial for understanding all areas of biology. A potentially revealing hypothesis for mutation-rate evolution is that natural selection primarily operates to improve replication fidelity, with the ultimate limits to what can be achieved set by the power of random genetic drift. This drift-barrier hypothesis is consistent with comparative measures of mutation rates, provides a simple explanation for the existence of error-prone polymerases and yields a formal counter-argument to the view that selection fine-tunes gene-specific mutation rates.

AB - As one of the few cellular traits that can be quantified across the tree of life, DNA-replication fidelity provides an excellent platform for understanding fundamental evolutionary processes. Furthermore, because mutation is the ultimate source of all genetic variation, clarifying why mutation rates vary is crucial for understanding all areas of biology. A potentially revealing hypothesis for mutation-rate evolution is that natural selection primarily operates to improve replication fidelity, with the ultimate limits to what can be achieved set by the power of random genetic drift. This drift-barrier hypothesis is consistent with comparative measures of mutation rates, provides a simple explanation for the existence of error-prone polymerases and yields a formal counter-argument to the view that selection fine-tunes gene-specific mutation rates.

UR - http://www.scopus.com/inward/record.url?scp=84991712897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991712897&partnerID=8YFLogxK

U2 - 10.1038/nrg.2016.104

DO - 10.1038/nrg.2016.104

M3 - Review article

C2 - 27739533

AN - SCOPUS:84991712897

VL - 17

SP - 704

EP - 714

JO - Nature Reviews Genetics

JF - Nature Reviews Genetics

SN - 1471-0056

IS - 11

ER -