Genetic And Developmental Basis Of F2 Hybrid Breakdown In Nasonia Parasitoid Wasps

J. D. Gibson, O. Niehuis, B. R E Peirson, E. I. Cash, Juergen Gadau

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Speciation is responsible for the vast diversity of life, and hybrid inviability, by reducing gene flow between populations, is a major contributor to this process. In the parasitoid wasp genus Nasonia, F2 hybrid males of Nasonia vitripennis and Nasonia giraulti experience an increased larval mortality rate relative to the parental species. Previous studies indicated that this increase of mortality is a consequence of incompatibilities between multiple nuclear loci and cytoplasmic factors of the parental species, but could only explain ~40% of the mortality rate in hybrids with N. giraulti cytoplasm. Here we report a locus on chromosome 5 that can explain the remaining mortality in this cross. We show that hybrid larvae that carry the incompatible allele on chromosome 5 halt growth early in their development and that ~98% die before they reach adulthood. On the basis of these new findings, we identified a nuclear-encoded OXPHOS gene as a strong candidate for being causally involved in the observed hybrid breakdown, suggesting that the incompatible mitochondrial locus is one of the six mitochondrial-encoded NADH genes. By identifying both genetic and physiological mechanisms that reduce gene flow between species, our results provide valuable and novel insights into the evolutionary dynamics of speciation.

Original languageEnglish (US)
Pages (from-to)2124-2132
Number of pages9
JournalEvolution
Volume67
Issue number7
DOIs
StatePublished - Jul 2013

Keywords

  • Cytonuclear incompatibility
  • mitochondria
  • oxidative phosphorylation
  • speciation

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)

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    Gibson, J. D., Niehuis, O., Peirson, B. R. E., Cash, E. I., & Gadau, J. (2013). Genetic And Developmental Basis Of F2 Hybrid Breakdown In Nasonia Parasitoid Wasps. Evolution, 67(7), 2124-2132. https://doi.org/10.1111/evo.12080