Genetic analysis of riboswitch-mediated transcriptional regulation responding to Mn2+ in Salmonella

Yixin Shi; Guang Zhao; Wei Kong

doi:10.1074/jbc.M113.517516

Genetic analysis of riboswitch-mediated transcriptional regulation responding to Mn²⁺ in Salmonella

Yixin Shi, Guang Zhao, Wei Kong

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: Divalent cation binding to riboswitch RNAs regulates expression of their transporter genes in bacteria. Results:Mn²⁺ interacts with Salmonella riboswitches characterized fromMn²⁺ transporter mntH andMg²⁺ transporter mgtA to modulate transcription of the downstream coding region. Conclusion: Specific riboswitches control gene expression in response to Mn²⁺ in bacteria. Significance: This is the discovery of a Mn²⁺ riboswitch.

Original language	English (US)
Pages (from-to)	11353-11366
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	289
Issue number	16
DOIs	https://doi.org/10.1074/jbc.M113.517516
State	Published - Apr 18 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Genetic analysis of riboswitch-mediated transcriptional regulation responding to Mn2+ in Salmonella",

abstract = "Background: Divalent cation binding to riboswitch RNAs regulates expression of their transporter genes in bacteria. Results:Mn2+ interacts with Salmonella riboswitches characterized fromMn2+ transporter mntH andMg2+ transporter mgtA to modulate transcription of the downstream coding region. Conclusion: Specific riboswitches control gene expression in response to Mn2+ in bacteria. Significance: This is the discovery of a Mn2+ riboswitch.",

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AU - Zhao, Guang

AU - Kong, Wei

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AB - Background: Divalent cation binding to riboswitch RNAs regulates expression of their transporter genes in bacteria. Results:Mn2+ interacts with Salmonella riboswitches characterized fromMn2+ transporter mntH andMg2+ transporter mgtA to modulate transcription of the downstream coding region. Conclusion: Specific riboswitches control gene expression in response to Mn2+ in bacteria. Significance: This is the discovery of a Mn2+ riboswitch.

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