Abstract
Background: Divalent cation binding to riboswitch RNAs regulates expression of their transporter genes in bacteria. Results:Mn2+ interacts with Salmonella riboswitches characterized fromMn2+ transporter mntH andMg2+ transporter mgtA to modulate transcription of the downstream coding region. Conclusion: Specific riboswitches control gene expression in response to Mn2+ in bacteria. Significance: This is the discovery of a Mn2+ riboswitch.
Original language | English (US) |
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Pages (from-to) | 11353-11366 |
Number of pages | 14 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 16 |
DOIs | |
State | Published - Apr 18 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology