Genetic analysis of cystic fibrosis using linked DNA markers

L. C. Tsui, K. Buetow, M. Buchwald

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Genetic linkage has been analyzed between cystic fibrosis (CF) and a number of markers on the long arm of chromosome 7, including D7S15, COL1A2, PON, MET, D7S8, and TCRB, using a cohort of 47 Canadian and 13 Danish CF families. The analysis confirms the previous observations that both MET and D7S8 are closely linked to CF. Based on the result from one family, MET appears to be more proximal to the centromere than CF. Our analysis also suggests that genetic heterogeneity may occur for the high recombination fraction between CF and D7S8 observed in another family. In addition, a strong linkage disequilibrium has been observed between CF and the two closely flanking markers.

Original languageEnglish (US)
Pages (from-to)720-728
Number of pages9
JournalAmerican Journal of Human Genetics
Volume39
Issue number6
StatePublished - Dec 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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