Gene survival and death on the human y chromosome

Melissa Wilson Sayres, Kateryna D. Makova

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Y chromosomes have long been dismissed as "graveyards of genes," but there is still much to be learned from the genetic relics of genes that were once functional on the human Y. We identified human X-linked genes whose gametologs have been pseudogenized or completely lost from the Y chromosome and inferred which evolutionary forces may be acting to retain genes on the Y. Although gene loss appears to be largely correlated with the suppression of recombination, we observe that X-linked genes with functional Y homologs evolve under stronger purifying selection and are expressed at higher levels than X-linked genes with nonfunctional Y homologs. Additionally, we support and expand upon the hypothesis that X inactivation is primarily driven by gene loss on the Y. Using linear discriminant analysis, we show that X-inactivation status can successfully classify 90% of X-linked genes into those with functional or nonfunctional Y homologs.

Original languageEnglish (US)
Pages (from-to)781-787
Number of pages7
JournalMolecular Biology and Evolution
Volume30
Issue number4
DOIs
StatePublished - Apr 2013
Externally publishedYes

Fingerprint

Human Chromosomes
X-Linked Genes
chromosome
death
chromosomes
Survival
gene
X Chromosome Inactivation
Genes
Y Chromosome
genes
Cemeteries
Y chromosome
Discriminant Analysis
Genetic Recombination
inactivation
discriminant analysis
recombination

Keywords

  • dosage compensation
  • evolution
  • human sex chromosomes
  • X-chromosome inactivation
  • Y degeneration

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Gene survival and death on the human y chromosome. / Wilson Sayres, Melissa; Makova, Kateryna D.

In: Molecular Biology and Evolution, Vol. 30, No. 4, 04.2013, p. 781-787.

Research output: Contribution to journalArticle

Wilson Sayres, Melissa ; Makova, Kateryna D. / Gene survival and death on the human y chromosome. In: Molecular Biology and Evolution. 2013 ; Vol. 30, No. 4. pp. 781-787.
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