Abstract
In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer's disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 311-322 |
| Number of pages | 12 |
| Journal | Physiological Genomics |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 12 2007 |
| Externally published | Yes |
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Keywords
- Affymetrix microarrays
- Alzheimer's disease
- Expression profiling
- Laser capture microdissection
- Neuron
- Transcriptomics
ASJC Scopus subject areas
- Physiology
- Genetics
Cite this
Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. / Liang, Winnie S.; Dunckley, Travis; Beach, Thomas G.; Grover, Andrew; Mastroeni, Diego; Walker, Douglas G.; Caselli, Richard J.; Kukull, Walter A.; McKeel, Daniel; Morris, John C.; Hulette, Christine; Schmechel, Donald; Alexander, Gene E.; Reiman, Eric M.; Rogers, Joseph; Stephan, Dietrich A.
In: Physiological Genomics, Vol. 28, No. 3, 12.02.2007, p. 311-322.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain
AU - Liang, Winnie S.
AU - Dunckley, Travis
AU - Beach, Thomas G.
AU - Grover, Andrew
AU - Mastroeni, Diego
AU - Walker, Douglas G.
AU - Caselli, Richard J.
AU - Kukull, Walter A.
AU - McKeel, Daniel
AU - Morris, John C.
AU - Hulette, Christine
AU - Schmechel, Donald
AU - Alexander, Gene E.
AU - Reiman, Eric M.
AU - Rogers, Joseph
AU - Stephan, Dietrich A.
PY - 2007/2/12
Y1 - 2007/2/12
N2 - In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer's disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders.
AB - In this article, we have characterized and compared gene expression profiles from laser capture microdissected neurons in six functionally and anatomically distinct regions from clinically and histopathologically normal aged human brains. These regions, which are also known to be differentially vulnerable to the histopathological and metabolic features of Alzheimer's disease (AD), include the entorhinal cortex and hippocampus (limbic and paralimbic areas vulnerable to early neurofibrillary tangle pathology in AD), posterior cingulate cortex (a paralimbic area vulnerable to early metabolic abnormalities in AD), temporal and prefrontal cortex (unimodal and heteromodal sensory association areas vulnerable to early neuritic plaque pathology in AD), and primary visual cortex (a primary sensory area relatively spared in early AD). These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders.
KW - Affymetrix microarrays
KW - Alzheimer's disease
KW - Expression profiling
KW - Laser capture microdissection
KW - Neuron
KW - Transcriptomics
UR - http://www.scopus.com/inward/record.url?scp=34247202571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247202571&partnerID=8YFLogxK
U2 - 10.1152/physiolgenomics.00208.2006
DO - 10.1152/physiolgenomics.00208.2006
M3 - Article
C2 - 17077275
AN - SCOPUS:34247202571
VL - 28
SP - 311
EP - 322
JO - Physiological Genomics
JF - Physiological Genomics
SN - 1094-8341
IS - 3
ER -