Gender differences in the risk for chronic renal allograft failure

H. U. Meier-Kriesche, A. O. Ojo, S. F. Leavey, J. A. Hanson, A. B. Leichtman, J. C. Magee, D. M. Cibrik, Bruce Kaplan

Research output: Contribution to journalArticle

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Abstract

Background. Despite the known differences in immunological reactivity between males and females, no differences in graft survival have been described among renal transplant recipients with regard to gender. To address this paradox, we analyzed data from 73,477 primary renal transplants collected in the US Renal Data System database. Methods. Logistic regression and Cox proportional hazard models were used to investigate the primary study end points, graft loss secondary to acute rejection (AR) or chronic allograft failure (CAF). CAF was defined as graft loss beyond 6 months, not attributable to death, recurrent disease, acute rejection, thrombosis, infection, noncompliance, or technical problems. The models adjusted for 15 covariates including immunosuppressive regimen, and donor and recipient characteristics. Results. The overall 8-year graft and patient survivals were significantly better in female renal transplant recipients compared with male recipients. However graft survival censored for death was not significantly different by gender. By multivariate analysis, females had a 10% increased odds of AR (OR=1.10, CI 1.02-1.12), but conversely a 10% lower risk of graft loss secondary to CAF (RR=0.9, CI 0.85-0.96). The risk for CAF increased significantly with increasing age for both males and females, but this effect was greater for males than for females (P

Original languageEnglish (US)
Pages (from-to)429-432
Number of pages4
JournalTransplantation
Volume71
Issue number3
StatePublished - Feb 15 2001
Externally publishedYes

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Chronic Kidney Failure
Allografts
Graft Survival
Transplants
Kidney
Acute Disease
Immunosuppressive Agents
Proportional Hazards Models
Information Systems
Thrombosis
Multivariate Analysis
Logistic Models
Tissue Donors
Databases
Infection
Transplant Recipients

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Meier-Kriesche, H. U., Ojo, A. O., Leavey, S. F., Hanson, J. A., Leichtman, A. B., Magee, J. C., ... Kaplan, B. (2001). Gender differences in the risk for chronic renal allograft failure. Transplantation, 71(3), 429-432.

Gender differences in the risk for chronic renal allograft failure. / Meier-Kriesche, H. U.; Ojo, A. O.; Leavey, S. F.; Hanson, J. A.; Leichtman, A. B.; Magee, J. C.; Cibrik, D. M.; Kaplan, Bruce.

In: Transplantation, Vol. 71, No. 3, 15.02.2001, p. 429-432.

Research output: Contribution to journalArticle

Meier-Kriesche, HU, Ojo, AO, Leavey, SF, Hanson, JA, Leichtman, AB, Magee, JC, Cibrik, DM & Kaplan, B 2001, 'Gender differences in the risk for chronic renal allograft failure', Transplantation, vol. 71, no. 3, pp. 429-432.
Meier-Kriesche HU, Ojo AO, Leavey SF, Hanson JA, Leichtman AB, Magee JC et al. Gender differences in the risk for chronic renal allograft failure. Transplantation. 2001 Feb 15;71(3):429-432.
Meier-Kriesche, H. U. ; Ojo, A. O. ; Leavey, S. F. ; Hanson, J. A. ; Leichtman, A. B. ; Magee, J. C. ; Cibrik, D. M. ; Kaplan, Bruce. / Gender differences in the risk for chronic renal allograft failure. In: Transplantation. 2001 ; Vol. 71, No. 3. pp. 429-432.
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