Gelatin-Based Biomaterials For Tissue Engineering And Stem Cell Bioengineering

Mehdi Nikkhah, Mohsen Akbari, Arghya Paul, Adnan Memic, Alireza Dolatshahi-Pirouz, Ali Khademhosseini

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

Abstract

Gelatin is a biocompatible, biodegradable and fully absorbable biopolymer. These properties have attracted significant interests in the use of gelatin for a wide range of tissue engineering applications. This chapter covers the studies that focused on using gelatin-based biomaterials for cardiovascular, bone, hepatic, skin and corneal tissue engineering. It discusses the application of gelatin for wound healing and injectable fillers. Stem cells hold great a potential in tissue regeneration applications due to their self renewal capacity and differentiation toward specialized cell types. The chapter discusses various strategies that have been utilized to modulate stem cell behavior by altering the biochemical and biophysical properties of gelatin. Gelatin-based delivery systems have found success in gene and siRNA delivery, to induce the expression of therapeutic proteins or trigger gene silencing, respectively. Overall, gelatin based drug delivery systems have demonstrated great utility and versatility in many biomedical applications.

Original languageEnglish (US)
Title of host publicationBiomaterials from Nature for Advanced Devices and Therapies
PublisherWiley-Blackwell
Pages37-62
Number of pages26
ISBN (Electronic)9781119126218
ISBN (Print)9781118478059
DOIs
StatePublished - Jan 1 2016

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Keywords

  • Absorbable biopolymer
  • Biomedical applications
  • Cardiovascular diseases
  • Gelatin based drug delivery systems
  • Gelatin-based biomaterials
  • Stem cell bioengineering
  • Therapeutic proteins
  • Tissue engineering

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)

Cite this

Nikkhah, M., Akbari, M., Paul, A., Memic, A., Dolatshahi-Pirouz, A., & Khademhosseini, A. (2016). Gelatin-Based Biomaterials For Tissue Engineering And Stem Cell Bioengineering. In Biomaterials from Nature for Advanced Devices and Therapies (pp. 37-62). Wiley-Blackwell. https://doi.org/10.1002/9781119126218.ch3