Gamma interferon levels during Chlamydia trachomatis pneumonia in mice

D. M. Williams, B. G. Grubbs, J. Schachter, D. M. Magee

Research output: Contribution to journalComment/debatepeer-review

29 Scopus citations

Abstract

Host defense against murine Chlamydia trachomatis (mouse pneumonitis agent [MoPn]) in a murine model was investigated. Gamma interferon (IFN-γ) was produced in the lungs by both MoPn-susceptible nude athymic (nu/nu) and MoPn- resistant heterozygous (nu/+) mice. In vivo depletion of IFN-γ in nu/nu mice led to exacerbation of infection. Fluorescence-activated cell sorter analysis disclosed induction of GL3 antibody-positive cells (putatively γ/δ+ T cells) in nu/nu mouse lung during infection with MoPn. Treatment of nu/nu mice in vivo with antibody to NK cells (anti-asialo GM1 antibody) or to γ/δ cells (UC7-13D5) did not significantly decrease IFN-γ production in the lung. However, treatment of severe combined immunodeficiency mice (which lack γ/δ cells) with antibody to NK cells significantly reduced lung IFN-γ levels.

Original languageEnglish (US)
Pages (from-to)3556-3558
Number of pages3
JournalInfection and immunity
Volume61
Issue number8
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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