Future cancer research priorities in the USA: a Lancet Oncology Commission

Elizabeth M. Jaffee, Chi Van Dang, David B. Agus, Brian M. Alexander, Kenneth C. Anderson, Alan Ashworth, Anna Barker, Roshan Bastani, Sangeeta Bhatia, Jeffrey A. Bluestone, Otis Brawley, Atul J. Butte, Daniel G. Coit, Nancy E. Davidson, Mark Davis, Ronald A. DePinho, Robert B. Diasio, Giulio Draetta, A. Lindsay Frazier, Andrew FutrealSam S. Gambhir, Patricia A. Ganz, Levi Garraway, Stanton Gerson, Sumit Gupta, James Heath, Ruth I. Hoffman, Cliff Hudis, Chanita Hughes-Halbert, Ramy Ibrahim, Hossein Jadvar, Brian Kavanagh, Rick Kittles, Quynh Thu Le, Scott M. Lippman, David Mankoff, Elaine R. Mardis, Deborah K. Mayer, Kelly McMasters, Neal J. Meropol, Beverly Mitchell, Peter Naredi, Dean Ornish, Timothy M. Pawlik, Jeffrey Peppercorn, Martin G. Pomper, Derek Raghavan, Christine Ritchie, Sally W. Schwarz, Richard Sullivan, Richard Wahl, Jedd D. Wolchok, Sandra L. Wong, Alfred Yung

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

We are in the midst of a technological revolution that is providing new insights into human biology and cancer. In this era of big data, we are amassing large amounts of information that is transforming how we approach cancer treatment and prevention. Enactment of the Cancer Moonshot within the 21st Century Cures Act in the USA arrived at a propitious moment in the advancement of knowledge, providing nearly US$2 billion of funding for cancer research and precision medicine. In 2016, the Blue Ribbon Panel (BRP) set out a roadmap of recommendations designed to exploit new advances in cancer diagnosis, prevention, and treatment. Those recommendations provided a high-level view of how to accelerate the conversion of new scientific discoveries into effective treatments and prevention for cancer. The US National Cancer Institute is already implementing some of those recommendations. As experts in the priority areas identified by the BRP, we bolster those recommendations to implement this important scientific roadmap. In this Commission, we examine the BRP recommendations in greater detail and expand the discussion to include additional priority areas, including surgical oncology, radiation oncology, imaging, health systems and health disparities, regulation and financing, population science, and oncopolicy. We prioritise areas of research in the USA that we believe would accelerate efforts to benefit patients with cancer. Finally, we hope the recommendations in this report will facilitate new international collaborations to further enhance global efforts in cancer control.

Original languageEnglish (US)
Pages (from-to)e653-e706
JournalThe Lancet. Oncology
Volume18
Issue number11
DOIs
StatePublished - Nov 1 2017

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Research
Neoplasms
Precision Medicine
Radiation Oncology
National Cancer Institute (U.S.)
Health
Therapeutics
Population

ASJC Scopus subject areas

  • Oncology

Cite this

Jaffee, E. M., Dang, C. V., Agus, D. B., Alexander, B. M., Anderson, K. C., Ashworth, A., ... Yung, A. (2017). Future cancer research priorities in the USA: a Lancet Oncology Commission. The Lancet. Oncology, 18(11), e653-e706. https://doi.org/10.1016/S1470-2045(17)30698-8

Future cancer research priorities in the USA : a Lancet Oncology Commission. / Jaffee, Elizabeth M.; Dang, Chi Van; Agus, David B.; Alexander, Brian M.; Anderson, Kenneth C.; Ashworth, Alan; Barker, Anna; Bastani, Roshan; Bhatia, Sangeeta; Bluestone, Jeffrey A.; Brawley, Otis; Butte, Atul J.; Coit, Daniel G.; Davidson, Nancy E.; Davis, Mark; DePinho, Ronald A.; Diasio, Robert B.; Draetta, Giulio; Frazier, A. Lindsay; Futreal, Andrew; Gambhir, Sam S.; Ganz, Patricia A.; Garraway, Levi; Gerson, Stanton; Gupta, Sumit; Heath, James; Hoffman, Ruth I.; Hudis, Cliff; Hughes-Halbert, Chanita; Ibrahim, Ramy; Jadvar, Hossein; Kavanagh, Brian; Kittles, Rick; Le, Quynh Thu; Lippman, Scott M.; Mankoff, David; Mardis, Elaine R.; Mayer, Deborah K.; McMasters, Kelly; Meropol, Neal J.; Mitchell, Beverly; Naredi, Peter; Ornish, Dean; Pawlik, Timothy M.; Peppercorn, Jeffrey; Pomper, Martin G.; Raghavan, Derek; Ritchie, Christine; Schwarz, Sally W.; Sullivan, Richard; Wahl, Richard; Wolchok, Jedd D.; Wong, Sandra L.; Yung, Alfred.

In: The Lancet. Oncology, Vol. 18, No. 11, 01.11.2017, p. e653-e706.

Research output: Contribution to journalReview article

Jaffee, EM, Dang, CV, Agus, DB, Alexander, BM, Anderson, KC, Ashworth, A, Barker, A, Bastani, R, Bhatia, S, Bluestone, JA, Brawley, O, Butte, AJ, Coit, DG, Davidson, NE, Davis, M, DePinho, RA, Diasio, RB, Draetta, G, Frazier, AL, Futreal, A, Gambhir, SS, Ganz, PA, Garraway, L, Gerson, S, Gupta, S, Heath, J, Hoffman, RI, Hudis, C, Hughes-Halbert, C, Ibrahim, R, Jadvar, H, Kavanagh, B, Kittles, R, Le, QT, Lippman, SM, Mankoff, D, Mardis, ER, Mayer, DK, McMasters, K, Meropol, NJ, Mitchell, B, Naredi, P, Ornish, D, Pawlik, TM, Peppercorn, J, Pomper, MG, Raghavan, D, Ritchie, C, Schwarz, SW, Sullivan, R, Wahl, R, Wolchok, JD, Wong, SL & Yung, A 2017, 'Future cancer research priorities in the USA: a Lancet Oncology Commission', The Lancet. Oncology, vol. 18, no. 11, pp. e653-e706. https://doi.org/10.1016/S1470-2045(17)30698-8
Jaffee EM, Dang CV, Agus DB, Alexander BM, Anderson KC, Ashworth A et al. Future cancer research priorities in the USA: a Lancet Oncology Commission. The Lancet. Oncology. 2017 Nov 1;18(11):e653-e706. https://doi.org/10.1016/S1470-2045(17)30698-8
Jaffee, Elizabeth M. ; Dang, Chi Van ; Agus, David B. ; Alexander, Brian M. ; Anderson, Kenneth C. ; Ashworth, Alan ; Barker, Anna ; Bastani, Roshan ; Bhatia, Sangeeta ; Bluestone, Jeffrey A. ; Brawley, Otis ; Butte, Atul J. ; Coit, Daniel G. ; Davidson, Nancy E. ; Davis, Mark ; DePinho, Ronald A. ; Diasio, Robert B. ; Draetta, Giulio ; Frazier, A. Lindsay ; Futreal, Andrew ; Gambhir, Sam S. ; Ganz, Patricia A. ; Garraway, Levi ; Gerson, Stanton ; Gupta, Sumit ; Heath, James ; Hoffman, Ruth I. ; Hudis, Cliff ; Hughes-Halbert, Chanita ; Ibrahim, Ramy ; Jadvar, Hossein ; Kavanagh, Brian ; Kittles, Rick ; Le, Quynh Thu ; Lippman, Scott M. ; Mankoff, David ; Mardis, Elaine R. ; Mayer, Deborah K. ; McMasters, Kelly ; Meropol, Neal J. ; Mitchell, Beverly ; Naredi, Peter ; Ornish, Dean ; Pawlik, Timothy M. ; Peppercorn, Jeffrey ; Pomper, Martin G. ; Raghavan, Derek ; Ritchie, Christine ; Schwarz, Sally W. ; Sullivan, Richard ; Wahl, Richard ; Wolchok, Jedd D. ; Wong, Sandra L. ; Yung, Alfred. / Future cancer research priorities in the USA : a Lancet Oncology Commission. In: The Lancet. Oncology. 2017 ; Vol. 18, No. 11. pp. e653-e706.
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