TY - JOUR
T1 - Functional Hypoxia in Insects
T2 - Definition, Assessment, and Consequences for Physiology, Ecology, and Evolution
AU - Harrison, Jon
AU - Greenlee, Kendra J.
AU - Verberk, Wilco C.E.P.
N1 - Funding Information:
This review was partially supported by NSF IOS-1256745 and by assistance from the Wissenschaft Kolleg zu Berlin to J.F.H.; by NSF IOS-0953297, NSF IOS-1557940, and NCRR 5P30GM103332 to K.J.G.; and by an NWO-VIDI grant (016.161.321) to W.C.E.P.V.
Publisher Copyright:
© 2018 by Annual Reviews. All rights reserved.
PY - 2018/1/7
Y1 - 2018/1/7
N2 - Insects can experience functional hypoxia, a situation in which O 2 supply is inadequate to meet oxygen demand. Assessing when functional hypoxia occurs is complex, because responses are graded, age and tissue dependent, and compensatory. Here, we compare information gained from metabolomics and transcriptional approaches and by manipulation of the partial pressure of oxygen. Functional hypoxia produces graded damage, including damaged macromolecules and inflammation. Insects respond by compensatory physiological and morphological changes in the tracheal system, metabolic reorganization, and suppression of activity, feeding, and growth. There is evidence for functional hypoxia in eggs, near the end of juvenile instars, and during molting. Functional hypoxia is more likely in species with lower O 2 availability or transport capacities and when O 2 need is great. Functional hypoxia occurs normally during insect development and is a factor in mediating life-history trade-offs.
AB - Insects can experience functional hypoxia, a situation in which O 2 supply is inadequate to meet oxygen demand. Assessing when functional hypoxia occurs is complex, because responses are graded, age and tissue dependent, and compensatory. Here, we compare information gained from metabolomics and transcriptional approaches and by manipulation of the partial pressure of oxygen. Functional hypoxia produces graded damage, including damaged macromolecules and inflammation. Insects respond by compensatory physiological and morphological changes in the tracheal system, metabolic reorganization, and suppression of activity, feeding, and growth. There is evidence for functional hypoxia in eggs, near the end of juvenile instars, and during molting. Functional hypoxia is more likely in species with lower O 2 availability or transport capacities and when O 2 need is great. Functional hypoxia occurs normally during insect development and is a factor in mediating life-history trade-offs.
KW - HIF
KW - anoxia
KW - body size
KW - development
KW - growth
KW - hypoxia
KW - temperature
KW - ventilation
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U2 - 10.1146/annurev-ento-020117-043145
DO - 10.1146/annurev-ento-020117-043145
M3 - Review article
C2 - 28992421
AN - SCOPUS:85040702070
SN - 0066-4170
VL - 63
SP - 303
EP - 325
JO - Annual Review of Entomology
JF - Annual Review of Entomology
ER -