Abstract

Systems biology is a discipline that studies biological systems from a holistic and interdisciplinary perspective. It brings together biologists, mathematicians, computer scientists, physicists, and engineers, so it has both biology-oriented components and systems-oriented components. We applied several computational tools to analyze the bibliographic information of published articles in systems biology to answer the question: Did the research topics of systems biology become more biology-oriented or more systems-oriented from 1992 to 2013? We analyzed the metadata of 9923 articles on systems biology from the Web of Science database. We identified the most highly cited 330 references using computational tools and through close reading we divided them into nine categories of research types in systems biology. Interestingly, we found that articles in one category, namely, systems biology’s applications in medical research, increased tremendously. This finding was corroborated by computational analysis of the abstracts, which also suggested that the percentages of topics on vaccines, diseases, drugs and cancers increased over time. In addition, we analyzed the institutional backgrounds of the corresponding authors of those 9923 articles and identified the most highly cited 330 authors over time. We found that before the mid-1990s, systems-oriented scientists had made the most referenced contributions. However, in recent years, researchers from biology-oriented institutions not only represented a huge percentage of the total number of researchers, but also had made the most referenced contributions. Notably, interdisciplinary institutions only produced a small percentage of researchers, but had made disproportionate contributions to this field.

Original languageEnglish (US)
Article numbere0200929
JournalPLoS One
Volume13
Issue number7
DOIs
StatePublished - Jul 1 2018

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Systems Biology
Biological Sciences
Research
Research Personnel
researchers
Biological systems
Metadata
Biomedical Research
Reading
Vaccines
Databases
biomedical research
Engineers
engineers
biologists
Pharmaceutical Preparations
vaccines
Neoplasms
drugs
neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

From systems to biology : A computational analysis of the research articles on systems biology from 1992 to 2013. / Zou, Yawen; Laubichler, Manfred.

In: PLoS One, Vol. 13, No. 7, e0200929, 01.07.2018.

Research output: Contribution to journalArticle

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