From molecular to modular cell biology

Leland H. Hartwell, John J. Hopfield, Stanislas Leibler, Andrew W. Murray

Research output: Contribution to journalArticle

2528 Scopus citations

Abstract

Cellular functions, such as signal transmission, are carried out by 'modules' made up of many species of interacting molecules. Understanding how modules work has depended on combining phenomenological analysis with molecular studies. General principles that govern the structure and behaviour of modules may be discovered with help from synthetic sciences such as engineering and computer science, from stronger interactions between experiment and theory in cell biology, and from an appreciation of evolutionary constraints.

Original languageEnglish (US)
Pages (from-to)C47-C52
JournalNature
Volume402
Issue number6761 SUPPL. 1
DOIs
StatePublished - Dec 2 1999
Externally publishedYes

ASJC Scopus subject areas

  • General

Cite this

Hartwell, L. H., Hopfield, J. J., Leibler, S., & Murray, A. W. (1999). From molecular to modular cell biology. Nature, 402(6761 SUPPL. 1), C47-C52. https://doi.org/10.1038/35011540