TY - JOUR
T1 - 'Flooding in vivo' during the circadian phase of minimal cortisol secretion
T2 - anxiety and therapeutic success without adrenal cortical activation
AU - Curtis, G.
AU - Buxton, M.
AU - Lippman, D.
AU - Nesse, R.
AU - Wright, J.
PY - 1976/12/1
Y1 - 1976/12/1
N2 - Seven patients with maximally severe phobias for physical objects were treated by 'flooding in vivo', i.e., live confrontation with the feared object. Each reported to the laboratory for 3 hr on 5 separate occasions, all in the early evening during the circadian phase of minimal adrenal cortical activity. At 20 min intervals during each session, blood was taken for cortisol assay, and anxiety was self rated on a scale of 0 to 100. Treatment was carried out during the 2nd hr of the 3rd and 4th sessions. The remaining time provided control observations. By behavioral and subjective criteria, the treatment hours produced very intense anxiety. However, they failed to elevate plasma cortisol levels. The remission of the phobias was 100%. Anxiety, even when intense and dramatic, does not necessarily activate the adrenal cortex, and an adrenal 'stress' response is not necessary for the therapeutic effect.
AB - Seven patients with maximally severe phobias for physical objects were treated by 'flooding in vivo', i.e., live confrontation with the feared object. Each reported to the laboratory for 3 hr on 5 separate occasions, all in the early evening during the circadian phase of minimal adrenal cortical activity. At 20 min intervals during each session, blood was taken for cortisol assay, and anxiety was self rated on a scale of 0 to 100. Treatment was carried out during the 2nd hr of the 3rd and 4th sessions. The remaining time provided control observations. By behavioral and subjective criteria, the treatment hours produced very intense anxiety. However, they failed to elevate plasma cortisol levels. The remission of the phobias was 100%. Anxiety, even when intense and dramatic, does not necessarily activate the adrenal cortex, and an adrenal 'stress' response is not necessary for the therapeutic effect.
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M3 - Article
C2 - 1260072
AN - SCOPUS:0017286855
SN - 0006-3223
VL - 11
SP - 101
EP - 107
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 1
ER -