TY - JOUR
T1 - Fixed Bed Modeling of Nonsteroidal Anti-Inflammatory Drug Removal by Ion-Exchange in Synthetic Urine
T2 - Mass Removal or Toxicity Reduction?
AU - Landry, Kelly A.
AU - Boyer, Treavor
N1 - Funding Information:
We thank Dr. Nancy Denslow and Kevin Kroll at the University of Florida for their insights into ecotoxicity testing, and Dr. Guenther Hochhaus at the University of Florida for his assistance with sample analysis. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1315138 and the NSF CAREER grant CBET-1150790. Any opinions, findings, conclusions or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of NSF. This manuscript was improved by the thoughtful comments of three anonymous reviewers.
Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/9/5
Y1 - 2017/9/5
N2 - Ion-exchange removal of nonsteroidal anti-inflammatory drugs (NSAIDs) in synthetic urine can selectively remove pharmaceuticals with minimal coremoval of nutrients to enhance nutrient recovery efforts. However, the effect of endogenous metabolites in urine on ion-exchange removal, and the corresponding reduction in ecotoxicity potential of pharmaceuticals in treated urine entering the environment, is unknown. To assess treatment efficacy, this work paired predicted breakthrough curves determined by the homogeneous surface diffusion model to an in vitro bioassay to evaluate COX-1 inhibition. The presence of endogenous metabolites in urine significantly impacted pharmaceutical removal, by competing for ion-exchange sites on the resin and reducing the resin capacity for pharmaceuticals. This indicates ion-exchange would be ineffective at removing NSAIDs and other negatively charged compounds in urine. Due to hydrolysis of pharmaceutical metabolites back to the parent compound, treatment systems should be designed based on the ultimate pharmaceutical concentration in ureolyzed urine. Mass removal and COX-1 inhibition followed a nonlinear correlation and mixture toxicity followed the generalized concentration addition model. This work demonstrates the importance of evaluating removal of contaminants of emerging concern, such as pharmaceuticals, using a risk-based approach to ecotoxicity end points in conjunction with mass removal.
AB - Ion-exchange removal of nonsteroidal anti-inflammatory drugs (NSAIDs) in synthetic urine can selectively remove pharmaceuticals with minimal coremoval of nutrients to enhance nutrient recovery efforts. However, the effect of endogenous metabolites in urine on ion-exchange removal, and the corresponding reduction in ecotoxicity potential of pharmaceuticals in treated urine entering the environment, is unknown. To assess treatment efficacy, this work paired predicted breakthrough curves determined by the homogeneous surface diffusion model to an in vitro bioassay to evaluate COX-1 inhibition. The presence of endogenous metabolites in urine significantly impacted pharmaceutical removal, by competing for ion-exchange sites on the resin and reducing the resin capacity for pharmaceuticals. This indicates ion-exchange would be ineffective at removing NSAIDs and other negatively charged compounds in urine. Due to hydrolysis of pharmaceutical metabolites back to the parent compound, treatment systems should be designed based on the ultimate pharmaceutical concentration in ureolyzed urine. Mass removal and COX-1 inhibition followed a nonlinear correlation and mixture toxicity followed the generalized concentration addition model. This work demonstrates the importance of evaluating removal of contaminants of emerging concern, such as pharmaceuticals, using a risk-based approach to ecotoxicity end points in conjunction with mass removal.
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U2 - 10.1021/acs.est.7b02273
DO - 10.1021/acs.est.7b02273
M3 - Article
C2 - 28732156
AN - SCOPUS:85028995390
SN - 0013-936X
VL - 51
SP - 10072
EP - 10080
JO - Environmental Science & Technology
JF - Environmental Science & Technology
IS - 17
ER -