TY - JOUR
T1 - Fishing for prostanoids
T2 - Deciphering the developmental functions of cyclooxygenase-derived prostaglandins
AU - Cha, Yong I.
AU - Solnica-Krezel, Lilianna
AU - DuBois, Raymond N.
N1 - Funding Information:
We apologize for any omissions in citing other important works in this field. We would like to thank SK Dey and Christina Speirs for critical reading of the manuscript. This work is supported in part from the United States Public Health Services Grants RO-DK-62112 and P0-CA-77839 to RND and R01GM55101 and GM62883 to LSK. RND is the B.F. Byrd Professor of Molecular Oncology and the recipient of an NIH MERIT award (R37-DK47297). This research has been supported in part by a zebrafish initiative funded by the Vanderbilt University Academic Venture Capital Fund. We also thank the T.J. Martell Foundation and the National Colorectal Cancer Research Alliance for additional support.
PY - 2006/1/15
Y1 - 2006/1/15
N2 - Prostaglandin G/H synthases (PGHS), commonly referred to as cyclooxygenases (COX-1 and COX-2), catalyze a key step in the synthesis of biologically active prostaglandins (PGs), the conversion of arachidonic acid (AA) into prostaglandin H2 (PGH2). PGs have important functions in a variety of physiologic and pathologic settings, including inflammation, cardiovascular homeostasis, reproduction, and carcinogenesis. However, an evaluation of prostaglandin function in early development has been difficult due to the maternal contribution of prostaglandins from the uterus. The emergence of zebrafish as a model system has begun to provide some insights into the roles of this signaling cascade during vertebrate development. In zebrafish, COX-1 derived prostaglandins are required for two distinct stages of development, namely during gastrulation and segmentation. During gastrulation, PGE 2 signaling promotes cell motility, without altering the cell shape or directional migration of gastrulating cells. During segmentation, COX-1 signaling is also required for posterior mesoderm development, including the formation of vascular tube structures, angiogenesis of intersomitic vessels, and pronephros morphogenesis. We propose that deciphering the role for prostaglandin signaling in zebrafish development could yield insight and ultimately address the mechanistic details underlying various disease processes that result from perturbation of this pathway.
AB - Prostaglandin G/H synthases (PGHS), commonly referred to as cyclooxygenases (COX-1 and COX-2), catalyze a key step in the synthesis of biologically active prostaglandins (PGs), the conversion of arachidonic acid (AA) into prostaglandin H2 (PGH2). PGs have important functions in a variety of physiologic and pathologic settings, including inflammation, cardiovascular homeostasis, reproduction, and carcinogenesis. However, an evaluation of prostaglandin function in early development has been difficult due to the maternal contribution of prostaglandins from the uterus. The emergence of zebrafish as a model system has begun to provide some insights into the roles of this signaling cascade during vertebrate development. In zebrafish, COX-1 derived prostaglandins are required for two distinct stages of development, namely during gastrulation and segmentation. During gastrulation, PGE 2 signaling promotes cell motility, without altering the cell shape or directional migration of gastrulating cells. During segmentation, COX-1 signaling is also required for posterior mesoderm development, including the formation of vascular tube structures, angiogenesis of intersomitic vessels, and pronephros morphogenesis. We propose that deciphering the role for prostaglandin signaling in zebrafish development could yield insight and ultimately address the mechanistic details underlying various disease processes that result from perturbation of this pathway.
KW - Angiogenesis
KW - Cyclooxygenase
KW - Development
KW - Embryogenesis
KW - Gastrulation
KW - Prostaglandin
KW - Prostaglandin G/H synthases
KW - Prostaglandin receptors
KW - Zebrafish
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U2 - 10.1016/j.ydbio.2005.10.013
DO - 10.1016/j.ydbio.2005.10.013
M3 - Review article
C2 - 16310177
AN - SCOPUS:30044432923
SN - 0012-1606
VL - 289
SP - 263
EP - 272
JO - Developmental Biology
JF - Developmental Biology
IS - 2
ER -