@article{2a91e352c7a641798bcb2a0f43438edb,
title = "Fish polyomaviruses belong to two distinct evolutionary lineages",
abstract = "The Polyomaviridae is a diverse family of circular double-stranded DNA viruses. Polyomaviruses have been isolated from a wide array of animal hosts. An understanding of the evolutionary and ecological dynamics of these viruses is essential to understanding the pathogenicity of polyomaviruses. Using a high throughput sequencing approach, we identified a novel polyomavirus in an emerald notothen (Trematomus bernacchii) sampled in the Ross sea (Antarctica), expanding the known number of fish-associated polyomaviruses. Our analysis suggests that polyomaviruses belong to three main evolutionary clades; the first clade is made up of all recognized terrestrial polyomaviruses. The fish-associated polyomaviruses are not monophyletic, and belong to two divergent evolutionary lineages. The fish viruses provide evidence that the evolution of the key viral large T protein involves gain and loss of distinct domains.",
keywords = "Antarctica, Emerald notothen, Polyomaviridae, Trematomus bernacchii",
author = "{Van Doorslaer}, Koenraad and Simona Kraberger and Charlotte Austin and Kata Farkas and Melissa Bergeman and Emma Paunil and William Davison and Arvind Varsani",
note = "Funding Information: Received 18 January 2018; Accepted 27 February 2018 Author affiliations: 1School of Animal and Comparative Biomedical Sciences, University of Arizona, 1657 E Helen St., Tucson, AZ 85721, USA; 2Cancer Biology Graduate Interdisciplinary Program, Genetics Graduate Interdisciplinary Program, Bio5 Institute, and the University of Arizona Cancer Center University of Arizona, 1657 E Helen St., Tucson, AZ 85721, USA; 3The Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine and School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA; 4School of Biological Sciences, University of Canterbury, Christchurch, New Zealand; 5School of Environment, Natural Resources and Geography Bangor University Bangor, LL57 2UW, UK; 6Structural Biology Research Unit, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, 7925, South Africa. *Correspondence: Koenraad Van Doorslaer, vandoorslaer@email.arizona.edu; Arvind Varsani, arvind.varsani@asu.edu Keywords: Polyomaviridae; Antarctica; emerald notothen; Trematomus bernacchii. Abbreviations: PyV, polyomavirus; TbPyV1, Trematomus bernacchii polyomavirus type 1; T-Ag, large T antigen. All sequence data reported in this study has been deposited in GenBank (https://www.ncbi.nlm.nih.gov/genbank/) under accession number MG800627. Two supplementary figures are available with the online version of this article. Funding Information: K. V. D. is supported by a State of Arizona Improving Health TRIF and by the National Institute of Food and Agriculture, U.S. Department of Agriculture, Hatch NC229. The field work was supported by a grant (K057) awarded to W.D. from Antarctica New Zealand. The molecular work described in this study is supported by Center of Evolution and Medicine Venture Fund (Center of Evolution and Medicine, Arizona State University, USA) grant awarded to A.V. Publisher Copyright: {\textcopyright} 2018 The Authors.",
year = "2018",
month = apr,
doi = "10.1099/jgv.0.001041",
language = "English (US)",
volume = "99",
pages = "567--573",
journal = "Journal of General Virology",
issn = "0022-1317",
publisher = "Society for General Microbiology",
number = "4",
}