First glimpse of the crystal structure of Yaet's POTRA domains

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The Omp85/YaeT family of proteins, which are conserved from bacteria to human, catalyzes insertion and assembly of proteins in the outer membrane. The structure consists of a transmembrane β-barrel domain and a soluble polypeptide-transport-associated (POTRA) domain. The POTRA domain is critical for substrate recognition and perhaps substrate folding, while the β-barrel domain assists in membrane insertion. The resolution of the crystal structure of the POTRA domain of the Escherichia coli YaeT protein provides a possible molecular mechanism by which the diverse group of substrates is recognized. Knowledge gained from the crystal structure may also spur the development of a novel class of chemotherapeutic inhibitors.

Original languageEnglish (US)
Pages (from-to)649-651
Number of pages3
JournalACS Chemical Biology
Volume2
Issue number10
DOIs
StatePublished - Oct 2007

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Fingerprint Dive into the research topics of 'First glimpse of the crystal structure of Yaet's POTRA domains'. Together they form a unique fingerprint.

Cite this