Abstract
matrix presented Azepine-based cryptophycin mimics (+)-4 and (+)-5 have been designed and synthesized. Biological evaluation revealed modest in vitro activity against several human tumor cell lines, thereby supporting the utility of novel scaffolds for the design and synthesis of cryptophycin analogues.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4063-4066 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 3 |
| Issue number | 25 |
| DOIs | |
| State | Published - Dec 13 2001 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Fingerprint Dive into the research topics of 'First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues'. Together they form a unique fingerprint.
Cite this
Smith, A. B., Cho, Y. S., Zawacki, L. E., Hirschmann, R., & Pettit, G. (2001). First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues. Organic Letters, 3(25), 4063-4066. https://doi.org/10.1021/ol016799g