First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues

Amos B. Smith; Young Shin Cho; Lisa E. Zawacki; Ralph Hirschmann; George Pettit

doi:10.1021/ol016799g

First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues

Amos B. Smith, Young Shin Cho, Lisa E. Zawacki, Ralph Hirschmann, George Pettit

CLAS-NS: Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

matrix presented Azepine-based cryptophycin mimics (+)-4 and (+)-5 have been designed and synthesized. Biological evaluation revealed modest in vitro activity against several human tumor cell lines, thereby supporting the utility of novel scaffolds for the design and synthesis of cryptophycin analogues.

Original language	English (US)
Pages (from-to)	4063-4066
Number of pages	4
Journal	Organic Letters
Volume	3
Issue number	25
DOIs	https://doi.org/10.1021/ol016799g
State	Published - Dec 13 2001

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues",

abstract = "matrix presented Azepine-based cryptophycin mimics (+)-4 and (+)-5 have been designed and synthesized. Biological evaluation revealed modest in vitro activity against several human tumor cell lines, thereby supporting the utility of novel scaffolds for the design and synthesis of cryptophycin analogues.",

author = "Smith, {Amos B.} and Cho, {Young Shin} and Zawacki, {Lisa E.} and Ralph Hirschmann and George Pettit",

year = "2001",

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AU - Smith, Amos B.

AU - Cho, Young Shin

AU - Zawacki, Lisa E.

AU - Hirschmann, Ralph

AU - Pettit, George

PY - 2001/12/13

Y1 - 2001/12/13

N2 - matrix presented Azepine-based cryptophycin mimics (+)-4 and (+)-5 have been designed and synthesized. Biological evaluation revealed modest in vitro activity against several human tumor cell lines, thereby supporting the utility of novel scaffolds for the design and synthesis of cryptophycin analogues.

AB - matrix presented Azepine-based cryptophycin mimics (+)-4 and (+)-5 have been designed and synthesized. Biological evaluation revealed modest in vitro activity against several human tumor cell lines, thereby supporting the utility of novel scaffolds for the design and synthesis of cryptophycin analogues.

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First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues

Abstract

ASJC Scopus subject areas

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