First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues

Amos B. Smith, Young Shin Cho, Lisa E. Zawacki, Ralph Hirschmann, George Pettit

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

matrix presented Azepine-based cryptophycin mimics (+)-4 and (+)-5 have been designed and synthesized. Biological evaluation revealed modest in vitro activity against several human tumor cell lines, thereby supporting the utility of novel scaffolds for the design and synthesis of cryptophycin analogues.

Original languageEnglish (US)
Pages (from-to)4063-4066
Number of pages4
JournalOrganic Letters
Volume3
Issue number25
DOIs
StatePublished - Dec 13 2001

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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