Fibrinogen adsorption onto microwave plasma chemical vapor deposited diamond films

J. M. Garguilo, B. A. Davis, M. Buddie, F. A.M. Köck, R. J. Nemanich

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

This study investigates the haemocompatibility of diamond films and attempts to correlate the results to structural characteristics and surface termination. The samples evaluated consisted of polycrystalline and nanocrystalline diamond films, single crystal diamond, titanium and silicon. Raman spectroscopy detailed the sp3 and sp2 bonding configurations while surface morphology was imaged using atomic force microscopy. Initial contact angles of deionized water were obtained using the sessile drop method. Samples exposed to a hydrogen plasma, and thus hydrogen terminated, became more hydrophobic while samples oxidized by a nitric acid etch became more hydrophilic. The adsorption process of the human protein fibrinogen was then studied on each of the samples. The water contact angle for the MPCVD and single crystal diamond samples did not change, indicating little protein adsorption. Titanium and silicon samples became more hydrophilic as a result of adhered fibrinogen protein.

Original languageEnglish (US)
Pages (from-to)595-599
Number of pages5
JournalDiamond and Related Materials
Volume13
Issue number4-8
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

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Keywords

  • Biocompatibility
  • Diamond
  • Diamond properties and applications
  • MPCVD

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Chemistry(all)
  • Mechanical Engineering
  • Materials Chemistry
  • Electrical and Electronic Engineering

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