Fetuin-A does not explain ethnic disparity in cardiometabolic risk factors and subclinical atherosclerosis between hispanics and non-hispanic whites

Iyad Syoufi, Juraj Koska, Matthew J. Budoff, Peter D. Reaven

Research output: Contribution to journalArticle


Background: Fetuin-A has been associated with insulin resistance and inversely related with vascular calcification. The present study evaluated whether serum fetuin-A explains the ethnic disparity in the subclinical atherosclerosis and risk for diabetes between healthy Hispanic and non-Hispanic white (NHW) subjects. Methods: Fetuin-A was measured in serum of 76 age-matched healthy males (41 NHW, 35 Hispanics). Bodymass index, blood pressure, serum lipoprotein cholesterol and triglyceride levels, coronary artery calcium (CAC), fasting glucose and insulin concentrations, and plasma glucose levels 2 h after a 75-g oral glucose tolerance test were measured in all participants. Insulin resistance was estimated using the homeostasis model assessment (HOMA). Results: Fasting insulin, fasting and 2-h serum glucose, and HOMA values were all significantly higher in Hispanics (p < 0.05 for all), yet CAC trended lower and the prevalence of very high CAC (>400 Agatston score) was lower (P = 0.03). There was no statistically significant difference in serum fetuin-A when comparing Hispanics and NHW (P = 0.12). Furthermore, there was no correlation between fetuin-A levels and CAC (P = 0.9). Conclusions: Serum fetuin-A concentration was not associated with measures of insulin resistance or with preclinical atherosclerosis in Hispanics and NHW. These data indicate that the disparity in prevalence of insulin resistance, type 2 diabetes, and subclinical atherosclerosis between Hispanics and NHW does not appear attributable to differences in fetuin-A concentrations.

Original languageEnglish (US)
Pages (from-to)77-79
Number of pages3
JournalMetabolic Syndrome and Related Disorders
Issue number1
StatePublished - Feb 1 2011
Externally publishedYes


ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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