Fetal wound healing: An in vitro explant model

D. Andrew R Burd, Michael T. Longaker, N. Scott Adzick, Carolyn Compton, Michael R. Harrison, John W. Siebert, H. Paul Ehrlich

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The ability of fetal skin wounds to heal without scar formation is remarkable. The mechanisms that endow the fetus with this unique healing ability remain unknown. We have developed an in vitro explant model using fetal sheep skin to investigate fetal wound healing. This model eliminates the complex systemic mechanisms that modulate in vivo wound healing. We demonstrated that using an enriched medium, midgestation fetal sheep skin explants following wounding reepithelialized within 4 days. By 7 days after wounding the confluent epidermis was thicker, but the dermal wound remained open. This model demonstrates that it is possible to achieve conditions in culture that maintain tissue viability and support reepithelialization. This model may allow us to resolve some of the individual components that participate in the process of scarless fetal skin healing.

Original languageEnglish (US)
Pages (from-to)898-901
Number of pages4
JournalJournal of Pediatric Surgery
Volume25
Issue number8
DOIs
Publication statusPublished - 1990
Externally publishedYes

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Keywords

  • Fetal wound healing

ASJC Scopus subject areas

  • Surgery

Cite this

Burd, D. A. R., Longaker, M. T., Adzick, N. S., Compton, C., Harrison, M. R., Siebert, J. W., & Ehrlich, H. P. (1990). Fetal wound healing: An in vitro explant model. Journal of Pediatric Surgery, 25(8), 898-901. https://doi.org/10.1016/0022-3468(90)90199-J