Feature-level MALDI-MS characterization of in situ-synthesized peptide microarrays

Matthew P. Greving; Pallav Kumar; Zhan-Gong Zhao; Neal Woodbury

doi:10.1021/la903510y

Feature-level MALDI-MS characterization of in situ-synthesized peptide microarrays

Matthew P. Greving, Pallav Kumar, Zhan-Gong Zhao, Neal Woodbury

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Characterizing the chemical composition of microarray features is a difficult yet important task in the production of in situ-synthesized microarrays. Here, we describe a method to determine the chemical composition of microarray features, directly on the feature. This method utilizes nondiffusional chemical cleavage from the surface along with techniques from MALDI-MS tissue imaging, thereby making the chemical characterization of high-density microarray features simple, accurate, and amenable to high-throughput.

Original language	English (US)
Pages (from-to)	1456-1459
Number of pages	4
Journal	Langmuir
Volume	26
Issue number	3
DOIs	https://doi.org/10.1021/la903510y
State	Published - Feb 2 2010

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la903510y

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abstract = "Characterizing the chemical composition of microarray features is a difficult yet important task in the production of in situ-synthesized microarrays. Here, we describe a method to determine the chemical composition of microarray features, directly on the feature. This method utilizes nondiffusional chemical cleavage from the surface along with techniques from MALDI-MS tissue imaging, thereby making the chemical characterization of high-density microarray features simple, accurate, and amenable to high-throughput.",

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AU - Kumar, Pallav

AU - Zhao, Zhan-Gong

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Y1 - 2010/2/2

N2 - Characterizing the chemical composition of microarray features is a difficult yet important task in the production of in situ-synthesized microarrays. Here, we describe a method to determine the chemical composition of microarray features, directly on the feature. This method utilizes nondiffusional chemical cleavage from the surface along with techniques from MALDI-MS tissue imaging, thereby making the chemical characterization of high-density microarray features simple, accurate, and amenable to high-throughput.

AB - Characterizing the chemical composition of microarray features is a difficult yet important task in the production of in situ-synthesized microarrays. Here, we describe a method to determine the chemical composition of microarray features, directly on the feature. This method utilizes nondiffusional chemical cleavage from the surface along with techniques from MALDI-MS tissue imaging, thereby making the chemical characterization of high-density microarray features simple, accurate, and amenable to high-throughput.

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Feature-level MALDI-MS characterization of in situ-synthesized peptide microarrays

Abstract

ASJC Scopus subject areas

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