Abstract

Characterizing the chemical composition of microarray features is a difficult yet important task in the production of in situ-synthesized microarrays. Here, we describe a method to determine the chemical composition of microarray features, directly on the feature. This method utilizes nondiffusional chemical cleavage from the surface along with techniques from MALDI-MS tissue imaging, thereby making the chemical characterization of high-density microarray features simple, accurate, and amenable to high-throughput.

Original languageEnglish (US)
Pages (from-to)1456-1459
Number of pages4
JournalLangmuir
Volume26
Issue number3
DOIs
StatePublished - Feb 2 2010

Fingerprint

Microarrays
Peptides
peptides
chemical composition
cleavage
Chemical analysis
Throughput
Tissue
Imaging techniques

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Feature-level MALDI-MS characterization of in situ-synthesized peptide microarrays. / Greving, Matthew P.; Kumar, Pallav; Zhao, Zhan-Gong; Woodbury, Neal.

In: Langmuir, Vol. 26, No. 3, 02.02.2010, p. 1456-1459.

Research output: Contribution to journalArticle

Greving, Matthew P. ; Kumar, Pallav ; Zhao, Zhan-Gong ; Woodbury, Neal. / Feature-level MALDI-MS characterization of in situ-synthesized peptide microarrays. In: Langmuir. 2010 ; Vol. 26, No. 3. pp. 1456-1459.
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