Fast Electrochemical and Plasmonic Detection Reveals Multitime Scale Conformational Gating of Electron Transfer in Cytochrome c

Yan Wang, Hui Wang, Yuheng Chen, Yixian Wang, Hong Yuan Chen, Xiaonan Shan, Nongjian Tao

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Conformational fluctuations play a central role in the electron transfer reactions of molecules. Because the fluctuations can be extremely fast in kinetics and small in amplitude, a technique with fast temporal resolution and high conformational sensitivity is needed to follow the transient electron transfer processes. Here we report on an electrochemically controlled plasmonic detection technique capable of monitoring conformational changes in redox molecules with ns response time. Using the technique, we study the electron transfer reaction and the associated conformational gating of a redox protein (cytochrome c). The study reveals that the conformational gating takes place over a broad range of time scales, from microsecond to millisecond.

Original languageEnglish (US)
Pages (from-to)7244-7249
Number of pages6
JournalJournal of the American Chemical Society
Volume139
Issue number21
DOIs
StatePublished - May 31 2017

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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