Familial pancreatic adenocarcinoma in three generations. A case report and a review of the literature

D. Ehrenthal, L. Haeger, T. Griffin, Carolyn Compton

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Although scattered case reports of familial clustering of pancreatic cancer have appeared in the literature, hereditary factors have not been clearly associated with increased risk for this malignancy. The current report documents the familial occurrence of pancreatic adenocarcinoma in three women of consecutive generations who died of their disease at progressively younger ages. The diagnoses are histologically confirmed in all three cases. Although two of the women carried a single known risk factor for pancreatic carcinoma (cigarette smoking), a familial predisposition to this disease is strongly implicated. The case suggests that the role of inheritance in pancreatic carcinoma may merit further exploration.

Original languageEnglish (US)
Pages (from-to)1661-1664
Number of pages4
JournalCancer
Volume59
Issue number9
StatePublished - 1987
Externally publishedYes

Fingerprint

Adenocarcinoma
Pancreatic Neoplasms
Cluster Analysis
Smoking
Neoplasms
Pancreatic Carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Familial pancreatic adenocarcinoma in three generations. A case report and a review of the literature. / Ehrenthal, D.; Haeger, L.; Griffin, T.; Compton, Carolyn.

In: Cancer, Vol. 59, No. 9, 1987, p. 1661-1664.

Research output: Contribution to journalArticle

Ehrenthal, D. ; Haeger, L. ; Griffin, T. ; Compton, Carolyn. / Familial pancreatic adenocarcinoma in three generations. A case report and a review of the literature. In: Cancer. 1987 ; Vol. 59, No. 9. pp. 1661-1664.
@article{1ae3d4dfed204f68bea0fa03741edb8a,
title = "Familial pancreatic adenocarcinoma in three generations. A case report and a review of the literature",
abstract = "Although scattered case reports of familial clustering of pancreatic cancer have appeared in the literature, hereditary factors have not been clearly associated with increased risk for this malignancy. The current report documents the familial occurrence of pancreatic adenocarcinoma in three women of consecutive generations who died of their disease at progressively younger ages. The diagnoses are histologically confirmed in all three cases. Although two of the women carried a single known risk factor for pancreatic carcinoma (cigarette smoking), a familial predisposition to this disease is strongly implicated. The case suggests that the role of inheritance in pancreatic carcinoma may merit further exploration.",
author = "D. Ehrenthal and L. Haeger and T. Griffin and Carolyn Compton",
year = "1987",
language = "English (US)",
volume = "59",
pages = "1661--1664",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Familial pancreatic adenocarcinoma in three generations. A case report and a review of the literature

AU - Ehrenthal, D.

AU - Haeger, L.

AU - Griffin, T.

AU - Compton, Carolyn

PY - 1987

Y1 - 1987

N2 - Although scattered case reports of familial clustering of pancreatic cancer have appeared in the literature, hereditary factors have not been clearly associated with increased risk for this malignancy. The current report documents the familial occurrence of pancreatic adenocarcinoma in three women of consecutive generations who died of their disease at progressively younger ages. The diagnoses are histologically confirmed in all three cases. Although two of the women carried a single known risk factor for pancreatic carcinoma (cigarette smoking), a familial predisposition to this disease is strongly implicated. The case suggests that the role of inheritance in pancreatic carcinoma may merit further exploration.

AB - Although scattered case reports of familial clustering of pancreatic cancer have appeared in the literature, hereditary factors have not been clearly associated with increased risk for this malignancy. The current report documents the familial occurrence of pancreatic adenocarcinoma in three women of consecutive generations who died of their disease at progressively younger ages. The diagnoses are histologically confirmed in all three cases. Although two of the women carried a single known risk factor for pancreatic carcinoma (cigarette smoking), a familial predisposition to this disease is strongly implicated. The case suggests that the role of inheritance in pancreatic carcinoma may merit further exploration.

UR - http://www.scopus.com/inward/record.url?scp=0023233894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023233894&partnerID=8YFLogxK

M3 - Article

VL - 59

SP - 1661

EP - 1664

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 9

ER -