Abstract
Although scattered case reports of familial clustering of pancreatic cancer have appeared in the literature, hereditary factors have not been clearly associated with increased risk for this malignancy. The current report documents the familial occurrence of pancreatic adenocarcinoma in three women of consecutive generations who died of their disease at progressively younger ages. The diagnoses are histologically confirmed in all three cases. Although two of the women carried a single known risk factor for pancreatic carcinoma (cigarette smoking), a familial predisposition to this disease is strongly implicated. The case suggests that the role of inheritance in pancreatic carcinoma may merit further exploration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1661-1664 |
| Number of pages | 4 |
| Journal | Cancer |
| Volume | 59 |
| Issue number | 9 |
| State | Published - 1987 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Familial pancreatic adenocarcinoma in three generations. A case report and a review of the literature. / Ehrenthal, D.; Haeger, L.; Griffin, T.; Compton, Carolyn.
In: Cancer, Vol. 59, No. 9, 1987, p. 1661-1664.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Familial pancreatic adenocarcinoma in three generations. A case report and a review of the literature
AU - Ehrenthal, D.
AU - Haeger, L.
AU - Griffin, T.
AU - Compton, Carolyn
PY - 1987
Y1 - 1987
N2 - Although scattered case reports of familial clustering of pancreatic cancer have appeared in the literature, hereditary factors have not been clearly associated with increased risk for this malignancy. The current report documents the familial occurrence of pancreatic adenocarcinoma in three women of consecutive generations who died of their disease at progressively younger ages. The diagnoses are histologically confirmed in all three cases. Although two of the women carried a single known risk factor for pancreatic carcinoma (cigarette smoking), a familial predisposition to this disease is strongly implicated. The case suggests that the role of inheritance in pancreatic carcinoma may merit further exploration.
AB - Although scattered case reports of familial clustering of pancreatic cancer have appeared in the literature, hereditary factors have not been clearly associated with increased risk for this malignancy. The current report documents the familial occurrence of pancreatic adenocarcinoma in three women of consecutive generations who died of their disease at progressively younger ages. The diagnoses are histologically confirmed in all three cases. Although two of the women carried a single known risk factor for pancreatic carcinoma (cigarette smoking), a familial predisposition to this disease is strongly implicated. The case suggests that the role of inheritance in pancreatic carcinoma may merit further exploration.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023233894&partnerID=8YFLogxK
M3 - Article
VL - 59
SP - 1661
EP - 1664
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 9
ER -