Familial insulin resistance and acanthosis nigricans: Presence of a postbinding defect

W. F. Schwenk, R. A. Rizza, L. J. Mandarino, J. E. Gerich, A. B. Hayles, M. W. Haymond

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Type A insulin resistance, associated with acanthosis nigricans and menstrual irregularity, has been ascribed to a decreased concentration of insulin receptors. We now report four affected females from one family, a mother and three daughters (including identical twins) who appear to have the type A syndrome. Two of the kindred had no apparent ovarian dysfunction, while the other two had hyperprolactinemia without other findings of polycystic ovary disease, suggesting a genetic disease with variable penetrance. All had normal erythrocyte and monocyte insulin binding. Insulin dose-response studies to assess glucose metabolism and insulin sensitivity were performed in the affected twins. The dose response to insulin was shifted to the right with a decrease in maximal response. These results are consistent with a postbinding defect in insulin action in these patients.

Original languageEnglish (US)
Pages (from-to)33-37
Number of pages5
JournalDiabetes
Volume35
Issue number1
StatePublished - 1986
Externally publishedYes

Fingerprint

Acanthosis Nigricans
Insulin Resistance
Insulin
Inborn Genetic Diseases
Hyperprolactinemia
Monozygotic Twins
Penetrance
Insulin Receptor
Nuclear Family
Monocytes
Ovary
Erythrocytes
Mothers
Glucose

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Schwenk, W. F., Rizza, R. A., Mandarino, L. J., Gerich, J. E., Hayles, A. B., & Haymond, M. W. (1986). Familial insulin resistance and acanthosis nigricans: Presence of a postbinding defect. Diabetes, 35(1), 33-37.

Familial insulin resistance and acanthosis nigricans : Presence of a postbinding defect. / Schwenk, W. F.; Rizza, R. A.; Mandarino, L. J.; Gerich, J. E.; Hayles, A. B.; Haymond, M. W.

In: Diabetes, Vol. 35, No. 1, 1986, p. 33-37.

Research output: Contribution to journalArticle

Schwenk, WF, Rizza, RA, Mandarino, LJ, Gerich, JE, Hayles, AB & Haymond, MW 1986, 'Familial insulin resistance and acanthosis nigricans: Presence of a postbinding defect', Diabetes, vol. 35, no. 1, pp. 33-37.
Schwenk WF, Rizza RA, Mandarino LJ, Gerich JE, Hayles AB, Haymond MW. Familial insulin resistance and acanthosis nigricans: Presence of a postbinding defect. Diabetes. 1986;35(1):33-37.
Schwenk, W. F. ; Rizza, R. A. ; Mandarino, L. J. ; Gerich, J. E. ; Hayles, A. B. ; Haymond, M. W. / Familial insulin resistance and acanthosis nigricans : Presence of a postbinding defect. In: Diabetes. 1986 ; Vol. 35, No. 1. pp. 33-37.
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