Extracellular recording of spatiotemporal patterning in response to odors in the olfactory epithelium by microelectrode arrays

Qingjun Liu, Ning Hu, Weiwei Ye, Hua Cai, Fenni Zhang, Ping Wang

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

In olfactory biosensors, microelectronic sensor chips combined with biological olfactory cells are a promising platform for odor detection. In our investigation, olfactory epithelium stripped from rat was fixed on the surface of microelectrode arrays (MEAs). Electrophysiological activities of olfactory receptor neurons in intact epithelium were measured in the form of extracellular potentials. Based on multi-channel recording performance of MEA and structural and functional integrality of native olfactory epithelium, the spatiotemporal analysis was carried out to study the extracellular activity pattern of neurons in the tissue. The variation of spatiotemporal patterns corresponding to different odors displayed the signals firing image characteristic intuitionally. It is an effective method in the form of patterns for monitoring the state of tissue both in time and space domain, promoting the platform for olfactory sensing mechanism research.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalBiosensors and Bioelectronics
Volume27
Issue number1
DOIs
StatePublished - Sep 15 2011
Externally publishedYes

Keywords

  • Cell based biosensor
  • Microelectrode array (MEA)
  • Olfactory epithelium
  • Olfactory sensor
  • Spatiotemporal patterning

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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