Expression of morphine-conditioned hyperactivity is attenuated by naloxone and pimozide

Janet Neisewander, M. T. Bardo

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The present experiments assessed whether morphine-conditioned hyperactivity could be attenuated by either the opiate antagonist naloxone or the dopamine antagonist pimozide. Both of these antagonists were shown to block the unconditioned hyperactivity induced by 2 mg/kg morphine (Experiment 1). Rats were then conditioned by pairing this dose of morphine repeatedly with a distinctive environment (Experiment 2). Following several drug-environment pairings, rats displayed a hyperactive conditioned response (CR) when exposed to the environment in the absence of the drug. CR expression was counteracted by 1 mg/kg naloxone and was attenuated by pimozide (0.25, 0.33, and 0.4 mg/kg) in a dose-related manner. These findings suggest that the unconditioned and conditioned hyperactive responses produced by morphine may involve similar neuropharmacologic substrates.

Original languageEnglish (US)
Pages (from-to)314-319
Number of pages6
JournalPsychopharmacology
Volume93
Issue number3
DOIs
StatePublished - Nov 1987
Externally publishedYes

Fingerprint

Pimozide
Naloxone
Morphine
Opiate Alkaloids
Dopamine Antagonists
Pharmaceutical Preparations

Keywords

  • Classical conditioning
  • Conditioned hyperactivity
  • Morphine
  • Naloxone
  • Pimozide

ASJC Scopus subject areas

  • Pharmacology

Cite this

Expression of morphine-conditioned hyperactivity is attenuated by naloxone and pimozide. / Neisewander, Janet; Bardo, M. T.

In: Psychopharmacology, Vol. 93, No. 3, 11.1987, p. 314-319.

Research output: Contribution to journalArticle

@article{cb5d32b554784d45aa8e2a531874a985,
title = "Expression of morphine-conditioned hyperactivity is attenuated by naloxone and pimozide",
abstract = "The present experiments assessed whether morphine-conditioned hyperactivity could be attenuated by either the opiate antagonist naloxone or the dopamine antagonist pimozide. Both of these antagonists were shown to block the unconditioned hyperactivity induced by 2 mg/kg morphine (Experiment 1). Rats were then conditioned by pairing this dose of morphine repeatedly with a distinctive environment (Experiment 2). Following several drug-environment pairings, rats displayed a hyperactive conditioned response (CR) when exposed to the environment in the absence of the drug. CR expression was counteracted by 1 mg/kg naloxone and was attenuated by pimozide (0.25, 0.33, and 0.4 mg/kg) in a dose-related manner. These findings suggest that the unconditioned and conditioned hyperactive responses produced by morphine may involve similar neuropharmacologic substrates.",
keywords = "Classical conditioning, Conditioned hyperactivity, Morphine, Naloxone, Pimozide",
author = "Janet Neisewander and Bardo, {M. T.}",
year = "1987",
month = "11",
doi = "10.1007/BF00187249",
language = "English (US)",
volume = "93",
pages = "314--319",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Expression of morphine-conditioned hyperactivity is attenuated by naloxone and pimozide

AU - Neisewander, Janet

AU - Bardo, M. T.

PY - 1987/11

Y1 - 1987/11

N2 - The present experiments assessed whether morphine-conditioned hyperactivity could be attenuated by either the opiate antagonist naloxone or the dopamine antagonist pimozide. Both of these antagonists were shown to block the unconditioned hyperactivity induced by 2 mg/kg morphine (Experiment 1). Rats were then conditioned by pairing this dose of morphine repeatedly with a distinctive environment (Experiment 2). Following several drug-environment pairings, rats displayed a hyperactive conditioned response (CR) when exposed to the environment in the absence of the drug. CR expression was counteracted by 1 mg/kg naloxone and was attenuated by pimozide (0.25, 0.33, and 0.4 mg/kg) in a dose-related manner. These findings suggest that the unconditioned and conditioned hyperactive responses produced by morphine may involve similar neuropharmacologic substrates.

AB - The present experiments assessed whether morphine-conditioned hyperactivity could be attenuated by either the opiate antagonist naloxone or the dopamine antagonist pimozide. Both of these antagonists were shown to block the unconditioned hyperactivity induced by 2 mg/kg morphine (Experiment 1). Rats were then conditioned by pairing this dose of morphine repeatedly with a distinctive environment (Experiment 2). Following several drug-environment pairings, rats displayed a hyperactive conditioned response (CR) when exposed to the environment in the absence of the drug. CR expression was counteracted by 1 mg/kg naloxone and was attenuated by pimozide (0.25, 0.33, and 0.4 mg/kg) in a dose-related manner. These findings suggest that the unconditioned and conditioned hyperactive responses produced by morphine may involve similar neuropharmacologic substrates.

KW - Classical conditioning

KW - Conditioned hyperactivity

KW - Morphine

KW - Naloxone

KW - Pimozide

UR - http://www.scopus.com/inward/record.url?scp=0023638543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023638543&partnerID=8YFLogxK

U2 - 10.1007/BF00187249

DO - 10.1007/BF00187249

M3 - Article

VL - 93

SP - 314

EP - 319

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 3

ER -