Exposure to Power-Frequency Magnetic Fields and the Risk of Infertility and Adverse Pregnancy Outcomes: Update on the Human Evidence and Recommendations for Future Study Designs

Ryan C. Lewis, Russ Hauser, Andrew Maynard, Richard L. Neitzel, Lu Wang, Robert Kavet, John D. Meeker

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Infertility and adverse pregnancy outcomes are significant public health concerns with global prevalence. Over the past 35 years, research has addressed whether exposure to power-frequency magnetic fields is one of the etiologic factors attributed to these conditions. However, no apparent authoritative reviews on this topic have been published in the peer-reviewed literature for nearly 15 years. This review provides an overview and critical analysis of human studies that were published in the peer-reviewed literature between 2002 and July 2015. Using PubMed, 13 epidemiology studies published during this time frame that concern exposure to magnetic fields and adverse prenatal (e.g., miscarriage), neonatal (e.g., preterm birth or birth defects), and male fertility (e.g., poor semen quality) outcomes were identified. Some of these studies reported associations whereas others did not, and study design limitations may explain these inconsistencies. Future investigations need to be designed with these limitations in mind to address existing research gaps. In particular, the following issues are discussed: (1) importance of selecting the appropriate study population, (2) need for addressing confounding due to unmeasured physical activity, (3) importance of minimizing information bias from exposure measurement error, (4) consideration of alternative magnetic field exposure metrics, and (5) implications and applications of personal exposure data that are correlated within female-male couples. Further epidemiologic research is needed, given the near ubiquitous exposures to power-frequency magnetic fields in the general population.

Original languageEnglish (US)
Pages (from-to)29-45
Number of pages17
JournalJournal of Toxicology and Environmental Health - Part B: Critical Reviews
Volume19
Issue number1
DOIs
StatePublished - Jan 2 2016
Externally publishedYes

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Magnetic Fields
Pregnancy Outcome
Infertility
Magnetic fields
Research
Epidemiology
Semen Analysis
Premature Birth
Public health
Spontaneous Abortion
Measurement errors
PubMed
Population
Fertility
Public Health
Defects

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Exposure to Power-Frequency Magnetic Fields and the Risk of Infertility and Adverse Pregnancy Outcomes : Update on the Human Evidence and Recommendations for Future Study Designs. / Lewis, Ryan C.; Hauser, Russ; Maynard, Andrew; Neitzel, Richard L.; Wang, Lu; Kavet, Robert; Meeker, John D.

In: Journal of Toxicology and Environmental Health - Part B: Critical Reviews, Vol. 19, No. 1, 02.01.2016, p. 29-45.

Research output: Contribution to journalArticle

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