Exploring gradients in electrophoretic separation and preconcentration on miniaturized devices

Fanyi Zhu; Mark A. Hayes

doi:10.3390/separations3020012

Exploring gradients in electrophoretic separation and preconcentration on miniaturized devices

Fanyi Zhu, Mark A. Hayes

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Over the last two decades, miniaturization, integration, and automation have made microfluidic systems popular. Core to advances in microfluidics are numerous electrophoretic separation and preconcentration strategies, some finding their origins on bench-top systems. Among them, gradient-based strategies are especially effective in addressing sensitivity challenges. This review introduces several gradient-based techniques according to a broad definition, including conductivity, field, and concentration, organized by the method of gradient generation. Each technique is introduced and described, and recent seminal advances explored.

Original language	English (US)
Article number	12
Journal	Separations
Volume	3
Issue number	2
DOIs	https://doi.org/10.3390/separations3020012
State	Published - Jun 2016

Keywords

Electrophoretic separation
Gradient
Microdevice
Preconcentration

ASJC Scopus subject areas

Analytical Chemistry
Filtration and Separation

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10.3390/separations3020012

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title = "Exploring gradients in electrophoretic separation and preconcentration on miniaturized devices",

abstract = "Over the last two decades, miniaturization, integration, and automation have made microfluidic systems popular. Core to advances in microfluidics are numerous electrophoretic separation and preconcentration strategies, some finding their origins on bench-top systems. Among them, gradient-based strategies are especially effective in addressing sensitivity challenges. This review introduces several gradient-based techniques according to a broad definition, including conductivity, field, and concentration, organized by the method of gradient generation. Each technique is introduced and described, and recent seminal advances explored.",

keywords = "Electrophoretic separation, Gradient, Microdevice, Preconcentration",

author = "Fanyi Zhu and Hayes, {Mark A.}",

note = "Funding Information: Acknowledgments: This work was supported by National Institutes of Health grants 5R21EB010191-02, 1R03AI094193-01, 1R03AI099740-01, and R03AI111361-01. Publisher Copyright: {\textcopyright} 2016 by the authors; licensee MDPI, Basel, Switzerland.",

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language = "English (US)",

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AU - Hayes, Mark A.

N1 - Funding Information: Acknowledgments: This work was supported by National Institutes of Health grants 5R21EB010191-02, 1R03AI094193-01, 1R03AI099740-01, and R03AI111361-01. Publisher Copyright: © 2016 by the authors; licensee MDPI, Basel, Switzerland.

PY - 2016/6

Y1 - 2016/6

N2 - Over the last two decades, miniaturization, integration, and automation have made microfluidic systems popular. Core to advances in microfluidics are numerous electrophoretic separation and preconcentration strategies, some finding their origins on bench-top systems. Among them, gradient-based strategies are especially effective in addressing sensitivity challenges. This review introduces several gradient-based techniques according to a broad definition, including conductivity, field, and concentration, organized by the method of gradient generation. Each technique is introduced and described, and recent seminal advances explored.

AB - Over the last two decades, miniaturization, integration, and automation have made microfluidic systems popular. Core to advances in microfluidics are numerous electrophoretic separation and preconcentration strategies, some finding their origins on bench-top systems. Among them, gradient-based strategies are especially effective in addressing sensitivity challenges. This review introduces several gradient-based techniques according to a broad definition, including conductivity, field, and concentration, organized by the method of gradient generation. Each technique is introduced and described, and recent seminal advances explored.

KW - Electrophoretic separation

KW - Gradient

KW - Microdevice

KW - Preconcentration

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ER -

Exploring gradients in electrophoretic separation and preconcentration on miniaturized devices

Abstract

Keywords

ASJC Scopus subject areas

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