Experimental lymph node metastases

enhanced detection with MR lymphography

R. Weissleder, G. Elizondo, L. Josephson, Carolyn Compton, C. J. Fretz, D. D. Stark, J. T. Ferrucci

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Magnetic resonance (MR) lymphography with superparamagnetic iron oxide (AMI-25) as a contrast agent was developed in an animal model with tumor-bearing lymph nodes. After interstitial administration of 20 μmol of iron per kilogram of body weight into the footpads of rats, the T2 of popliteal and paraaortic lymph nodes decreased from 67 msec ± 8.2 to 9.5 msec ± 0.9 and 9.3 msec ± 0.9, respectively. T2 relaxation times of lymph nodes containing metastases showed a significantly higher value (61 msec ± 6.2, P < .005) after interstitial administration of the contrast agent. Intravenous administration of AMI-25 did not produce enhancement of normal or metastatic lymph node relaxation times. The signal intensity of normal lymph nodes decreased profoundly on spin-echo MR images (repetition time of 500 msec, echo time of 30 msec) after interstitial administration, whereas lymph nodes with metastases showed no significant change in signal intensity. Experimental results indicate that MR lymphography may potentially increase the sensitivity of MR imaging in the detection of lymphatic malignancy.

Original languageEnglish (US)
Pages (from-to)835-839
Number of pages5
JournalRadiology
Volume171
Issue number3
StatePublished - 1989
Externally publishedYes

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Lymphography
Magnetic Resonance Spectroscopy
Lymph Nodes
Neoplasm Metastasis
ferrous sulfate
Contrast Media
Intravenous Administration
Neoplasms
Animal Models
Body Weight
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Weissleder, R., Elizondo, G., Josephson, L., Compton, C., Fretz, C. J., Stark, D. D., & Ferrucci, J. T. (1989). Experimental lymph node metastases: enhanced detection with MR lymphography. Radiology, 171(3), 835-839.

Experimental lymph node metastases : enhanced detection with MR lymphography. / Weissleder, R.; Elizondo, G.; Josephson, L.; Compton, Carolyn; Fretz, C. J.; Stark, D. D.; Ferrucci, J. T.

In: Radiology, Vol. 171, No. 3, 1989, p. 835-839.

Research output: Contribution to journalArticle

Weissleder, R, Elizondo, G, Josephson, L, Compton, C, Fretz, CJ, Stark, DD & Ferrucci, JT 1989, 'Experimental lymph node metastases: enhanced detection with MR lymphography', Radiology, vol. 171, no. 3, pp. 835-839.
Weissleder R, Elizondo G, Josephson L, Compton C, Fretz CJ, Stark DD et al. Experimental lymph node metastases: enhanced detection with MR lymphography. Radiology. 1989;171(3):835-839.
Weissleder, R. ; Elizondo, G. ; Josephson, L. ; Compton, Carolyn ; Fretz, C. J. ; Stark, D. D. ; Ferrucci, J. T. / Experimental lymph node metastases : enhanced detection with MR lymphography. In: Radiology. 1989 ; Vol. 171, No. 3. pp. 835-839.
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