Experimental configurational landscapes in aqueous solutions

John L. Finney, Daniel T. Bowron, P. G. Wolynes, P. Barnes, M. Karplus, P. F. McMillan, F. Fernandez-Alonso, Charles Angell

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Structures arid interactions between molecules in solution are modulated by the solvent. Changes in solvent conditions can lead to structural changes and transitions such as the assembly processes seen in micelle formation and protein folding. In the case of even quite complex liquid systems, we can now explore experimentally the configurational energy landscapes that underlie these processes. Using an aqueous solution of an amphiphile as an example, the structural transitions induced by changes in temperature, concentration and added salt are examined at the molecular level, and some critical regions of the landscape identified. Moreover, the potentials of mean force that quantitatively describe the solvent-modulated interaction between molecules in solution can now be experimentally accessed.

Original languageEnglish (US)
Pages (from-to)469-492
Number of pages24
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume363
Issue number1827
DOIs
StatePublished - Feb 15 2005

Keywords

  • Amphiphiles
  • Aqueous solutions
  • Concentration dependence
  • Potential of mean force
  • Salting out
  • Temperature dependence

ASJC Scopus subject areas

  • Mathematics(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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    Finney, J. L., Bowron, D. T., Wolynes, P. G., Barnes, P., Karplus, M., McMillan, P. F., Fernandez-Alonso, F., & Angell, C. (2005). Experimental configurational landscapes in aqueous solutions. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 363(1827), 469-492. https://doi.org/10.1098/rsta.2004.1503