TY - JOUR
T1 - Excessive Daytime Sleepiness in Major Dementia Syndromes
AU - Boeve, Angelica
AU - Ferman, Tanis J.
AU - Aakre, Jeremiah
AU - St. Louis, Erik
AU - Silber, Michael
AU - Machulda, Mary
AU - Fields, Julie
AU - Graff-Radford, Neill
AU - Mielke, Michelle
AU - Geda, Yonas
AU - Jones, David
AU - Graff-Radford, Jonathon
AU - Knopman, David
AU - Petersen, Ronald
AU - Boeve, Brad
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer’s disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P <.05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P <.01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.
AB - There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer’s disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P <.05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P <.01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.
KW - Alzheimer’s disease
KW - dementia with Lewy bodies
KW - excessive daytime sleepiness
KW - frontotemporal dementia
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U2 - 10.1177/1533317519828046
DO - 10.1177/1533317519828046
M3 - Article
C2 - 30740984
AN - SCOPUS:85061561638
SN - 1533-3175
VL - 34
SP - 261
EP - 264
JO - American Journal of Alzheimer's Disease and Other Dementias
JF - American Journal of Alzheimer's Disease and Other Dementias
IS - 4
ER -