Exceptionally high levels of recombination across the honey bee genome

Martin Beye, Irene Gattermeier, Martin Hasselmann, Tanja Gempe, Morten Schioett, John F. Baines, David Schlipalius, Florence Mougel, Christine Emore, Olav Rueppell, Anu Sirviö, Ernesto Guzmán-Novoa, Greg Hunt, Michel Solignac, Robert Page

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

The first draft of the honey bee genome sequence and improved genetic maps are utilized to analyze a genome displaying 10 times higher levels of recombination (19 cM/Mb) than previously analyzed genomes of higher eukaryotes. The exceptionally high recombination rate is distributed genome-wide, but varies by two orders of magnitude. Analysis of chromosome, sequence, and gene parameters with respect to recombination showed that local recombination rate is associated with distance to the telomere, GC content, and the number of simple repeats as described for low-recombining genomes. Recombination rate does not decrease with chromosome size. On average 5.7 recombination events per chromosome pair per meiosis are found in the honey bee genome. This contrasts with a wide range of taxa that have a uniform recombination frequency of about 1.6 per chromosome pair. The excess of recombination activity does not support a mechanistic role of recombination in stabilizing pairs of homologous chromosome during chromosome pairing. Recombination rate is associated with gene size, suggesting that introns are larger in regions of low recombination and may improve the efficacy of selection in these regions. Very few transposons and no retrotransposons are present in the high-recombining genome. We propose evolutionary explanations for the exceptionally high genome-wide recombination rate.

Original languageEnglish (US)
Pages (from-to)1339-1344
Number of pages6
JournalGenome Research
Volume16
Issue number11
DOIs
StatePublished - 2006

Fingerprint

Honey
Bees
Genetic Recombination
Genome
Chromosomes
Chromosome Pairing
Retroelements
Telomere
Base Composition
Meiosis
Eukaryota
Introns
Genes
Sequence Analysis

ASJC Scopus subject areas

  • Genetics

Cite this

Beye, M., Gattermeier, I., Hasselmann, M., Gempe, T., Schioett, M., Baines, J. F., ... Page, R. (2006). Exceptionally high levels of recombination across the honey bee genome. Genome Research, 16(11), 1339-1344. https://doi.org/10.1101/gr.5680406

Exceptionally high levels of recombination across the honey bee genome. / Beye, Martin; Gattermeier, Irene; Hasselmann, Martin; Gempe, Tanja; Schioett, Morten; Baines, John F.; Schlipalius, David; Mougel, Florence; Emore, Christine; Rueppell, Olav; Sirviö, Anu; Guzmán-Novoa, Ernesto; Hunt, Greg; Solignac, Michel; Page, Robert.

In: Genome Research, Vol. 16, No. 11, 2006, p. 1339-1344.

Research output: Contribution to journalArticle

Beye, M, Gattermeier, I, Hasselmann, M, Gempe, T, Schioett, M, Baines, JF, Schlipalius, D, Mougel, F, Emore, C, Rueppell, O, Sirviö, A, Guzmán-Novoa, E, Hunt, G, Solignac, M & Page, R 2006, 'Exceptionally high levels of recombination across the honey bee genome', Genome Research, vol. 16, no. 11, pp. 1339-1344. https://doi.org/10.1101/gr.5680406
Beye M, Gattermeier I, Hasselmann M, Gempe T, Schioett M, Baines JF et al. Exceptionally high levels of recombination across the honey bee genome. Genome Research. 2006;16(11):1339-1344. https://doi.org/10.1101/gr.5680406
Beye, Martin ; Gattermeier, Irene ; Hasselmann, Martin ; Gempe, Tanja ; Schioett, Morten ; Baines, John F. ; Schlipalius, David ; Mougel, Florence ; Emore, Christine ; Rueppell, Olav ; Sirviö, Anu ; Guzmán-Novoa, Ernesto ; Hunt, Greg ; Solignac, Michel ; Page, Robert. / Exceptionally high levels of recombination across the honey bee genome. In: Genome Research. 2006 ; Vol. 16, No. 11. pp. 1339-1344.
@article{ca067bcef59947a1822035430b66b715,
title = "Exceptionally high levels of recombination across the honey bee genome",
abstract = "The first draft of the honey bee genome sequence and improved genetic maps are utilized to analyze a genome displaying 10 times higher levels of recombination (19 cM/Mb) than previously analyzed genomes of higher eukaryotes. The exceptionally high recombination rate is distributed genome-wide, but varies by two orders of magnitude. Analysis of chromosome, sequence, and gene parameters with respect to recombination showed that local recombination rate is associated with distance to the telomere, GC content, and the number of simple repeats as described for low-recombining genomes. Recombination rate does not decrease with chromosome size. On average 5.7 recombination events per chromosome pair per meiosis are found in the honey bee genome. This contrasts with a wide range of taxa that have a uniform recombination frequency of about 1.6 per chromosome pair. The excess of recombination activity does not support a mechanistic role of recombination in stabilizing pairs of homologous chromosome during chromosome pairing. Recombination rate is associated with gene size, suggesting that introns are larger in regions of low recombination and may improve the efficacy of selection in these regions. Very few transposons and no retrotransposons are present in the high-recombining genome. We propose evolutionary explanations for the exceptionally high genome-wide recombination rate.",
author = "Martin Beye and Irene Gattermeier and Martin Hasselmann and Tanja Gempe and Morten Schioett and Baines, {John F.} and David Schlipalius and Florence Mougel and Christine Emore and Olav Rueppell and Anu Sirvi{\"o} and Ernesto Guzm{\'a}n-Novoa and Greg Hunt and Michel Solignac and Robert Page",
year = "2006",
doi = "10.1101/gr.5680406",
language = "English (US)",
volume = "16",
pages = "1339--1344",
journal = "Genome Research",
issn = "1088-9051",
publisher = "Cold Spring Harbor Laboratory Press",
number = "11",

}

TY - JOUR

T1 - Exceptionally high levels of recombination across the honey bee genome

AU - Beye, Martin

AU - Gattermeier, Irene

AU - Hasselmann, Martin

AU - Gempe, Tanja

AU - Schioett, Morten

AU - Baines, John F.

AU - Schlipalius, David

AU - Mougel, Florence

AU - Emore, Christine

AU - Rueppell, Olav

AU - Sirviö, Anu

AU - Guzmán-Novoa, Ernesto

AU - Hunt, Greg

AU - Solignac, Michel

AU - Page, Robert

PY - 2006

Y1 - 2006

N2 - The first draft of the honey bee genome sequence and improved genetic maps are utilized to analyze a genome displaying 10 times higher levels of recombination (19 cM/Mb) than previously analyzed genomes of higher eukaryotes. The exceptionally high recombination rate is distributed genome-wide, but varies by two orders of magnitude. Analysis of chromosome, sequence, and gene parameters with respect to recombination showed that local recombination rate is associated with distance to the telomere, GC content, and the number of simple repeats as described for low-recombining genomes. Recombination rate does not decrease with chromosome size. On average 5.7 recombination events per chromosome pair per meiosis are found in the honey bee genome. This contrasts with a wide range of taxa that have a uniform recombination frequency of about 1.6 per chromosome pair. The excess of recombination activity does not support a mechanistic role of recombination in stabilizing pairs of homologous chromosome during chromosome pairing. Recombination rate is associated with gene size, suggesting that introns are larger in regions of low recombination and may improve the efficacy of selection in these regions. Very few transposons and no retrotransposons are present in the high-recombining genome. We propose evolutionary explanations for the exceptionally high genome-wide recombination rate.

AB - The first draft of the honey bee genome sequence and improved genetic maps are utilized to analyze a genome displaying 10 times higher levels of recombination (19 cM/Mb) than previously analyzed genomes of higher eukaryotes. The exceptionally high recombination rate is distributed genome-wide, but varies by two orders of magnitude. Analysis of chromosome, sequence, and gene parameters with respect to recombination showed that local recombination rate is associated with distance to the telomere, GC content, and the number of simple repeats as described for low-recombining genomes. Recombination rate does not decrease with chromosome size. On average 5.7 recombination events per chromosome pair per meiosis are found in the honey bee genome. This contrasts with a wide range of taxa that have a uniform recombination frequency of about 1.6 per chromosome pair. The excess of recombination activity does not support a mechanistic role of recombination in stabilizing pairs of homologous chromosome during chromosome pairing. Recombination rate is associated with gene size, suggesting that introns are larger in regions of low recombination and may improve the efficacy of selection in these regions. Very few transposons and no retrotransposons are present in the high-recombining genome. We propose evolutionary explanations for the exceptionally high genome-wide recombination rate.

UR - http://www.scopus.com/inward/record.url?scp=33750514832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750514832&partnerID=8YFLogxK

U2 - 10.1101/gr.5680406

DO - 10.1101/gr.5680406

M3 - Article

C2 - 17065604

AN - SCOPUS:33750514832

VL - 16

SP - 1339

EP - 1344

JO - Genome Research

JF - Genome Research

SN - 1088-9051

IS - 11

ER -