Examination of streptococcal gene expression in the mammalian environment

W. Todd Grey, Joshua D. Lasker, Roy Curtiss, Michael C. Hudson

Research output: Contribution to journalArticlepeer-review

Abstract

Laboratory studies of bacterial gene expression have not allowed the investigation of in vivo factors crucial to pathogenesis. Recently, genetic tools have been used to identify in vivo-activated genes. These tools, however, have not allowed the measurement of specific expression levels of virulence-associated bacterial genes in vivo, This report describes a system, previously tested utilizing the fructosyltransferase (ftf) gene of Streptococcus mutans, that allows the measurement of activity of specific virulence-associated streptococcal genes while bacteria are living in the animal environment.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalMethods in Cell Science
Volume20
Issue number1-4
DOIs
StatePublished - Dec 1 1998

Keywords

  • Gene expression
  • Mammalian environment
  • Streptococcus

ASJC Scopus subject areas

  • Cell Biology

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