Evolutionary molecular medicine

Randolph M. Nesse; Detlev Ganten; T. Ryan Gregory; Gilbert S. Omenn

doi:10.1007/s00109-012-0889-9

Evolutionary molecular medicine

Randolph M. Nesse, Detlev Ganten, T. Ryan Gregory, Gilbert S. Omenn

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.

Original language	English (US)
Pages (from-to)	509-522
Number of pages	14
Journal	Journal of Molecular Medicine
Volume	90
Issue number	5
DOIs	https://doi.org/10.1007/s00109-012-0889-9
State	Published - May 2012
Externally published	Yes

Keywords

Biology
Darwinian medicine
Evolution
Evolutionary medicine
Evolutionary molecular medicine
Genetics

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Genetics(clinical)

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10.1007/s00109-012-0889-9

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title = "Evolutionary molecular medicine",

abstract = "Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.",

keywords = "Biology, Darwinian medicine, Evolution, Evolutionary medicine, Evolutionary molecular medicine, Genetics",

author = "Nesse, {Randolph M.} and Detlev Ganten and Gregory, {T. Ryan} and Omenn, {Gilbert S.}",

note = "Funding Information: Acknowledgments Warm thanks to Margit Burmeister, Bernard Crespi, Alan Rogers, Srijan Sen, an anonymous reviewer, and members of the Evolution and Human Adaptation Program Laboratory group at the University of Michigan for helpful comments that improved this manuscript. GSO acknowledges support from NIH grants U54DA021519, UL1 RR024986, RM-08-029, and U54ES017885.",

year = "2012",

month = may,

doi = "10.1007/s00109-012-0889-9",

language = "English (US)",

volume = "90",

pages = "509--522",

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AU - Nesse, Randolph M.

AU - Ganten, Detlev

AU - Gregory, T. Ryan

AU - Omenn, Gilbert S.

N1 - Funding Information: Acknowledgments Warm thanks to Margit Burmeister, Bernard Crespi, Alan Rogers, Srijan Sen, an anonymous reviewer, and members of the Evolution and Human Adaptation Program Laboratory group at the University of Michigan for helpful comments that improved this manuscript. GSO acknowledges support from NIH grants U54DA021519, UL1 RR024986, RM-08-029, and U54ES017885.

PY - 2012/5

Y1 - 2012/5

N2 - Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.

AB - Evolution has long provided a foundation for population genetics, but some major advances in evolutionary biology from the twentieth century that provide foundations for evolutionary medicine are only now being applied in molecular medicine. They include the need for both proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, competition between alleles, co-evolution, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are transforming evolutionary biology in ways that create even more opportunities for progress at its interfaces with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and related principles to speed the development of evolutionary molecular medicine.

KW - Biology

KW - Darwinian medicine

KW - Evolution

KW - Evolutionary medicine

KW - Evolutionary molecular medicine

KW - Genetics

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DO - 10.1007/s00109-012-0889-9

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JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

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Evolutionary molecular medicine

Abstract

Keywords

ASJC Scopus subject areas

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