Evolutionary determinants of genome-wide nucleotide composition

Hongan Long, Way Sung, Sibel Kucukyildirim, Emily Williams, Samuel F. Miller, Wanfeng Guo, Caitlyn Patterson, Colin Gregory, Chloe Strauss, Casey Stone, Cécile Berne, David Kysela, William R. Shoemaker, Mario E. Muscarella, Haiwei Luo, Jay T. Lennon, Yves V. Brun, Michael Lynch

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

One of the long-standing mysteries of evolutionary genomics is the source of the wide phylogenetic diversity in genome nucleotide composition (G + C versus A + T), which must be a consequence of interspecific differences in mutation bias, the efficiency of selection for different nucleotides or a combination of the two. We demonstrate that although genomic G + C composition is strongly driven by mutation bias, it is also substantially modified by direct selection and/or as a by-product of biased gene conversion. Moreover, G + C composition at fourfold redundant sites is consistently elevated above the neutral expectation - more so than for any other class of sites.

Original languageEnglish (US)
Pages (from-to)237-240
Number of pages4
JournalNature Ecology and Evolution
Volume2
Issue number2
DOIs
StatePublished - Feb 1 2018

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mutation
genomics
genome
nucleotides
gene conversion
phylogenetics
gene
phylogeny
by-product

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

Cite this

Long, H., Sung, W., Kucukyildirim, S., Williams, E., Miller, S. F., Guo, W., ... Lynch, M. (2018). Evolutionary determinants of genome-wide nucleotide composition. Nature Ecology and Evolution, 2(2), 237-240. https://doi.org/10.1038/s41559-017-0425-y

Evolutionary determinants of genome-wide nucleotide composition. / Long, Hongan; Sung, Way; Kucukyildirim, Sibel; Williams, Emily; Miller, Samuel F.; Guo, Wanfeng; Patterson, Caitlyn; Gregory, Colin; Strauss, Chloe; Stone, Casey; Berne, Cécile; Kysela, David; Shoemaker, William R.; Muscarella, Mario E.; Luo, Haiwei; Lennon, Jay T.; Brun, Yves V.; Lynch, Michael.

In: Nature Ecology and Evolution, Vol. 2, No. 2, 01.02.2018, p. 237-240.

Research output: Contribution to journalArticle

Long, H, Sung, W, Kucukyildirim, S, Williams, E, Miller, SF, Guo, W, Patterson, C, Gregory, C, Strauss, C, Stone, C, Berne, C, Kysela, D, Shoemaker, WR, Muscarella, ME, Luo, H, Lennon, JT, Brun, YV & Lynch, M 2018, 'Evolutionary determinants of genome-wide nucleotide composition', Nature Ecology and Evolution, vol. 2, no. 2, pp. 237-240. https://doi.org/10.1038/s41559-017-0425-y
Long H, Sung W, Kucukyildirim S, Williams E, Miller SF, Guo W et al. Evolutionary determinants of genome-wide nucleotide composition. Nature Ecology and Evolution. 2018 Feb 1;2(2):237-240. https://doi.org/10.1038/s41559-017-0425-y
Long, Hongan ; Sung, Way ; Kucukyildirim, Sibel ; Williams, Emily ; Miller, Samuel F. ; Guo, Wanfeng ; Patterson, Caitlyn ; Gregory, Colin ; Strauss, Chloe ; Stone, Casey ; Berne, Cécile ; Kysela, David ; Shoemaker, William R. ; Muscarella, Mario E. ; Luo, Haiwei ; Lennon, Jay T. ; Brun, Yves V. ; Lynch, Michael. / Evolutionary determinants of genome-wide nucleotide composition. In: Nature Ecology and Evolution. 2018 ; Vol. 2, No. 2. pp. 237-240.
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