Evolutionary determinants of genome-wide nucleotide composition

Hongan Long; Way Sung; Sibel Kucukyildirim; Emily Williams; Samuel F. Miller; Wanfeng Guo; Caitlyn Patterson; Colin Gregory; Chloe Strauss; Casey Stone; Cécile Berne; David Kysela; William R. Shoemaker; Mario E. Muscarella; Haiwei Luo; Jay T. Lennon; Yves V. Brun; Michael Lynch

doi:10.1038/s41559-017-0425-y

Evolutionary determinants of genome-wide nucleotide composition

Hongan Long, Way Sung, Sibel Kucukyildirim, Emily Williams, Samuel F. Miller, Wanfeng Guo, Caitlyn Patterson, Colin Gregory, Chloe Strauss, Casey Stone, Cécile Berne, David Kysela, William R. Shoemaker, Mario E. Muscarella, Haiwei Luo, Jay T. Lennon, Yves V. Brun, Michael Lynch

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

One of the long-standing mysteries of evolutionary genomics is the source of the wide phylogenetic diversity in genome nucleotide composition (G + C versus A + T), which must be a consequence of interspecific differences in mutation bias, the efficiency of selection for different nucleotides or a combination of the two. We demonstrate that although genomic G + C composition is strongly driven by mutation bias, it is also substantially modified by direct selection and/or as a by-product of biased gene conversion. Moreover, G + C composition at fourfold redundant sites is consistently elevated above the neutral expectation - more so than for any other class of sites.

Original language	English (US)
Pages (from-to)	237-240
Number of pages	4
Journal	Nature Ecology and Evolution
Volume	2
Issue number	2
DOIs	https://doi.org/10.1038/s41559-017-0425-y
State	Published - Feb 1 2018

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Ecology

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Long, H., Sung, W., Kucukyildirim, S., Williams, E., Miller, S. F., Guo, W., Patterson, C., Gregory, C., Strauss, C., Stone, C., Berne, C., Kysela, D., Shoemaker, W. R., Muscarella, M. E., Luo, H., Lennon, J. T., Brun, Y. V., & Lynch, M. (2018). Evolutionary determinants of genome-wide nucleotide composition. Nature Ecology and Evolution, 2(2), 237-240. https://doi.org/10.1038/s41559-017-0425-y

Long, H, Sung, W, Kucukyildirim, S, Williams, E, Miller, SF, Guo, W, Patterson, C, Gregory, C, Strauss, C, Stone, C, Berne, C, Kysela, D, Shoemaker, WR, Muscarella, ME, Luo, H, Lennon, JT, Brun, YV & Lynch, M 2018, 'Evolutionary determinants of genome-wide nucleotide composition', Nature Ecology and Evolution, vol. 2, no. 2, pp. 237-240. https://doi.org/10.1038/s41559-017-0425-y

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AU - Patterson, Caitlyn

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Evolutionary determinants of genome-wide nucleotide composition

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