Evolutionary cell biology

Two origins, one objective

Michael Lynch, Mark C. Field, Holly V. Goodson, Harmit S. Malik, José B. Pereira-Leal, David S. Roos, Aaron P. Turkewitz, Shelley Sazer

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

All aspects of biological diversification ultimately trace to evolutionary modifications at the cellular level. This central role of cells frames the basic questions as to how cells work and how cells come to be the way they are. Although these two lines of inquiry lie respectively within the traditional provenance of cell biology and evolutionary biology, a comprehensive synthesis of evolutionary and cell-biological thinking is lacking. We define evolutionary cell biology as the fusion of these two eponymous fields with the theoretical and quantitative branches of biochemistry, biophysics, and population genetics. The key goals are to develop a mechanistic understanding of general evolutionary processes, while specifically infusing cell biology with an evolutionary perspective. The full development of this interdisciplinary field has the potential to solve numerous problems in diverse areas of biology, including the degree to which selection, effectively neutral processes, historical contingencies, and/or constraints at the chemical and biophysical levels dictate patterns of variation for intracellular features. These problems can now be examined at both the within- and among-species levels, with single-cell methodologies even allowing quantification of variation within genotypes. Some results from this emerging field have already had a substantial impact on cell biology, and future findings will significantly influence applications in agriculture, medicine, environmental science, and synthetic biology.

Original languageEnglish (US)
Pages (from-to)16990-16994
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume111
Issue number48
DOIs
StatePublished - Dec 2 2014
Externally publishedYes

Fingerprint

Cell Biology
Synthetic Biology
Biophysics
Population Genetics
Ecology
Agriculture
Biochemistry
Genotype
Medicine

Keywords

  • Adaptive evolution
  • Cell biology
  • Cellular evolution
  • Evolutionary cell biology
  • Random genetic drift

ASJC Scopus subject areas

  • General

Cite this

Lynch, M., Field, M. C., Goodson, H. V., Malik, H. S., Pereira-Leal, J. B., Roos, D. S., ... Sazer, S. (2014). Evolutionary cell biology: Two origins, one objective. Proceedings of the National Academy of Sciences of the United States of America, 111(48), 16990-16994. https://doi.org/10.1073/pnas.1415861111

Evolutionary cell biology : Two origins, one objective. / Lynch, Michael; Field, Mark C.; Goodson, Holly V.; Malik, Harmit S.; Pereira-Leal, José B.; Roos, David S.; Turkewitz, Aaron P.; Sazer, Shelley.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 48, 02.12.2014, p. 16990-16994.

Research output: Contribution to journalReview article

Lynch, M, Field, MC, Goodson, HV, Malik, HS, Pereira-Leal, JB, Roos, DS, Turkewitz, AP & Sazer, S 2014, 'Evolutionary cell biology: Two origins, one objective', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 48, pp. 16990-16994. https://doi.org/10.1073/pnas.1415861111
Lynch, Michael ; Field, Mark C. ; Goodson, Holly V. ; Malik, Harmit S. ; Pereira-Leal, José B. ; Roos, David S. ; Turkewitz, Aaron P. ; Sazer, Shelley. / Evolutionary cell biology : Two origins, one objective. In: Proceedings of the National Academy of Sciences of the United States of America. 2014 ; Vol. 111, No. 48. pp. 16990-16994.
@article{db6eaf08fc0f4245a409f0f68c13ce7c,
title = "Evolutionary cell biology: Two origins, one objective",
abstract = "All aspects of biological diversification ultimately trace to evolutionary modifications at the cellular level. This central role of cells frames the basic questions as to how cells work and how cells come to be the way they are. Although these two lines of inquiry lie respectively within the traditional provenance of cell biology and evolutionary biology, a comprehensive synthesis of evolutionary and cell-biological thinking is lacking. We define evolutionary cell biology as the fusion of these two eponymous fields with the theoretical and quantitative branches of biochemistry, biophysics, and population genetics. The key goals are to develop a mechanistic understanding of general evolutionary processes, while specifically infusing cell biology with an evolutionary perspective. The full development of this interdisciplinary field has the potential to solve numerous problems in diverse areas of biology, including the degree to which selection, effectively neutral processes, historical contingencies, and/or constraints at the chemical and biophysical levels dictate patterns of variation for intracellular features. These problems can now be examined at both the within- and among-species levels, with single-cell methodologies even allowing quantification of variation within genotypes. Some results from this emerging field have already had a substantial impact on cell biology, and future findings will significantly influence applications in agriculture, medicine, environmental science, and synthetic biology.",
keywords = "Adaptive evolution, Cell biology, Cellular evolution, Evolutionary cell biology, Random genetic drift",
author = "Michael Lynch and Field, {Mark C.} and Goodson, {Holly V.} and Malik, {Harmit S.} and Pereira-Leal, {Jos{\'e} B.} and Roos, {David S.} and Turkewitz, {Aaron P.} and Shelley Sazer",
year = "2014",
month = "12",
day = "2",
doi = "10.1073/pnas.1415861111",
language = "English (US)",
volume = "111",
pages = "16990--16994",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "48",

}

TY - JOUR

T1 - Evolutionary cell biology

T2 - Two origins, one objective

AU - Lynch, Michael

AU - Field, Mark C.

AU - Goodson, Holly V.

AU - Malik, Harmit S.

AU - Pereira-Leal, José B.

AU - Roos, David S.

AU - Turkewitz, Aaron P.

AU - Sazer, Shelley

PY - 2014/12/2

Y1 - 2014/12/2

N2 - All aspects of biological diversification ultimately trace to evolutionary modifications at the cellular level. This central role of cells frames the basic questions as to how cells work and how cells come to be the way they are. Although these two lines of inquiry lie respectively within the traditional provenance of cell biology and evolutionary biology, a comprehensive synthesis of evolutionary and cell-biological thinking is lacking. We define evolutionary cell biology as the fusion of these two eponymous fields with the theoretical and quantitative branches of biochemistry, biophysics, and population genetics. The key goals are to develop a mechanistic understanding of general evolutionary processes, while specifically infusing cell biology with an evolutionary perspective. The full development of this interdisciplinary field has the potential to solve numerous problems in diverse areas of biology, including the degree to which selection, effectively neutral processes, historical contingencies, and/or constraints at the chemical and biophysical levels dictate patterns of variation for intracellular features. These problems can now be examined at both the within- and among-species levels, with single-cell methodologies even allowing quantification of variation within genotypes. Some results from this emerging field have already had a substantial impact on cell biology, and future findings will significantly influence applications in agriculture, medicine, environmental science, and synthetic biology.

AB - All aspects of biological diversification ultimately trace to evolutionary modifications at the cellular level. This central role of cells frames the basic questions as to how cells work and how cells come to be the way they are. Although these two lines of inquiry lie respectively within the traditional provenance of cell biology and evolutionary biology, a comprehensive synthesis of evolutionary and cell-biological thinking is lacking. We define evolutionary cell biology as the fusion of these two eponymous fields with the theoretical and quantitative branches of biochemistry, biophysics, and population genetics. The key goals are to develop a mechanistic understanding of general evolutionary processes, while specifically infusing cell biology with an evolutionary perspective. The full development of this interdisciplinary field has the potential to solve numerous problems in diverse areas of biology, including the degree to which selection, effectively neutral processes, historical contingencies, and/or constraints at the chemical and biophysical levels dictate patterns of variation for intracellular features. These problems can now be examined at both the within- and among-species levels, with single-cell methodologies even allowing quantification of variation within genotypes. Some results from this emerging field have already had a substantial impact on cell biology, and future findings will significantly influence applications in agriculture, medicine, environmental science, and synthetic biology.

KW - Adaptive evolution

KW - Cell biology

KW - Cellular evolution

KW - Evolutionary cell biology

KW - Random genetic drift

UR - http://www.scopus.com/inward/record.url?scp=84914168998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84914168998&partnerID=8YFLogxK

U2 - 10.1073/pnas.1415861111

DO - 10.1073/pnas.1415861111

M3 - Review article

VL - 111

SP - 16990

EP - 16994

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 48

ER -