Evolutionary biology and the avoidance of antimicrobial resistance

Andrew F. Read, Silvie Huijben

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Evolutionary biologists have largely left the search for solutions to the drug resistance crisis to biomedical scientists, physicians, veterinarians and public health specialists. We believe this is because the vast majority of professional evolutionary biologists consider the evolutionary science of drug resistance to be conceptually uninteresting. Using malaria as case study, we argue that it is not. We review examples of evolutionary thinking that challenge various fallacies dominating antimalarial therapy, and discuss open problems that need evolutionary insight. These problems are unlikely to be resolved by biomedical scientists ungrounded in evolutionary biology. Involvement by evolutionary biologists in the science of drug resistance requires no intellectual compromises: The problems are as conceptually challenging as they are important.

Original languageEnglish (US)
Pages (from-to)40-51
Number of pages12
JournalEvolutionary Applications
Volume2
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • Antibiotic resistance
  • Drug resistance
  • Malaria
  • Plasmodium

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Evolutionary biology and the avoidance of antimicrobial resistance'. Together they form a unique fingerprint.

Cite this