Evolutionary biology and the avoidance of antimicrobial resistance

Andrew F. Read, Silvie Huijben

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Evolutionary biologists have largely left the search for solutions to the drug resistance crisis to biomedical scientists, physicians, veterinarians and public health specialists. We believe this is because the vast majority of professional evolutionary biologists consider the evolutionary science of drug resistance to be conceptually uninteresting. Using malaria as case study, we argue that it is not. We review examples of evolutionary thinking that challenge various fallacies dominating antimalarial therapy, and discuss open problems that need evolutionary insight. These problems are unlikely to be resolved by biomedical scientists ungrounded in evolutionary biology. Involvement by evolutionary biologists in the science of drug resistance requires no intellectual compromises: The problems are as conceptually challenging as they are important.

Original languageEnglish (US)
Pages (from-to)40-51
Number of pages12
JournalEvolutionary Applications
Volume2
Issue number1
DOIs
StatePublished - Feb 1 2009
Externally publishedYes

Fingerprint

drug resistance
evolutionary biology
Drug Resistance
antibiotic resistance
biologists
Biological Sciences
antimalarials
Veterinarians
malaria
Antimalarials
physicians
Malaria
veterinarians
public health
Public Health
case studies
Physicians
therapeutics
science
Therapeutics

Keywords

  • Antibiotic resistance
  • Drug resistance
  • Malaria
  • Plasmodium

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Agricultural and Biological Sciences(all)

Cite this

Evolutionary biology and the avoidance of antimicrobial resistance. / Read, Andrew F.; Huijben, Silvie.

In: Evolutionary Applications, Vol. 2, No. 1, 01.02.2009, p. 40-51.

Research output: Contribution to journalArticle

@article{9f52d3ff2a30408c8b1c791ec454dd80,
title = "Evolutionary biology and the avoidance of antimicrobial resistance",
abstract = "Evolutionary biologists have largely left the search for solutions to the drug resistance crisis to biomedical scientists, physicians, veterinarians and public health specialists. We believe this is because the vast majority of professional evolutionary biologists consider the evolutionary science of drug resistance to be conceptually uninteresting. Using malaria as case study, we argue that it is not. We review examples of evolutionary thinking that challenge various fallacies dominating antimalarial therapy, and discuss open problems that need evolutionary insight. These problems are unlikely to be resolved by biomedical scientists ungrounded in evolutionary biology. Involvement by evolutionary biologists in the science of drug resistance requires no intellectual compromises: The problems are as conceptually challenging as they are important.",
keywords = "Antibiotic resistance, Drug resistance, Malaria, Plasmodium",
author = "Read, {Andrew F.} and Silvie Huijben",
year = "2009",
month = "2",
day = "1",
doi = "10.1111/j.1752-4571.2008.00066.x",
language = "English (US)",
volume = "2",
pages = "40--51",
journal = "Evolutionary Applications",
issn = "1752-4563",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Evolutionary biology and the avoidance of antimicrobial resistance

AU - Read, Andrew F.

AU - Huijben, Silvie

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Evolutionary biologists have largely left the search for solutions to the drug resistance crisis to biomedical scientists, physicians, veterinarians and public health specialists. We believe this is because the vast majority of professional evolutionary biologists consider the evolutionary science of drug resistance to be conceptually uninteresting. Using malaria as case study, we argue that it is not. We review examples of evolutionary thinking that challenge various fallacies dominating antimalarial therapy, and discuss open problems that need evolutionary insight. These problems are unlikely to be resolved by biomedical scientists ungrounded in evolutionary biology. Involvement by evolutionary biologists in the science of drug resistance requires no intellectual compromises: The problems are as conceptually challenging as they are important.

AB - Evolutionary biologists have largely left the search for solutions to the drug resistance crisis to biomedical scientists, physicians, veterinarians and public health specialists. We believe this is because the vast majority of professional evolutionary biologists consider the evolutionary science of drug resistance to be conceptually uninteresting. Using malaria as case study, we argue that it is not. We review examples of evolutionary thinking that challenge various fallacies dominating antimalarial therapy, and discuss open problems that need evolutionary insight. These problems are unlikely to be resolved by biomedical scientists ungrounded in evolutionary biology. Involvement by evolutionary biologists in the science of drug resistance requires no intellectual compromises: The problems are as conceptually challenging as they are important.

KW - Antibiotic resistance

KW - Drug resistance

KW - Malaria

KW - Plasmodium

UR - http://www.scopus.com/inward/record.url?scp=66049114296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66049114296&partnerID=8YFLogxK

U2 - 10.1111/j.1752-4571.2008.00066.x

DO - 10.1111/j.1752-4571.2008.00066.x

M3 - Article

AN - SCOPUS:66049114296

VL - 2

SP - 40

EP - 51

JO - Evolutionary Applications

JF - Evolutionary Applications

SN - 1752-4563

IS - 1

ER -