Evolution and ecology of MHC molecules: From genomics to sexual selection

Scott V. Edwards, Philip W. Hedrick

Research output: Contribution to journalArticle

267 Citations (Scopus)

Abstract

In the past few years the DNA sequence database for molecules of the MHC (major histocompatibility complex) has expanded greatly, yielding a more complete picture of the long-term rates and patterns of evolution of the MHC in vertebrates. Sharing of MHC allelic lineages between long-diverged species (trans-species evolution) has been detected virtually wherever it is sought, but new analyses of linked neutral regions and the complexities of sequence convergence and microrecombination in the peptide binding region challenge traditional phylogenetic analyses. Methods for estimating the intensity of selection on MHC genes suggest that viability is important, but recent studies in natural populations of mammals give inconsistent results concerning mate choice. The complex and interacting roles of microrecombination, parasite-mediated selection and mating preferences for maintaining the extraordinary levels of MHC polymorphism observed are still difficult to evaluate.

Original languageEnglish (US)
Pages (from-to)305-311
Number of pages7
JournalTrends in Ecology and Evolution
Volume13
Issue number8
DOIs
StatePublished - Aug 1 1998

Fingerprint

major histocompatibility complex
sexual selection
genomics
ecology
mating behavior
selection intensity
mate choice
peptide
parasite
vertebrate
viability
polymorphism
mammal
vertebrates
genetic polymorphism
peptides
mammals
phylogenetics
nucleotide sequences
DNA

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

Cite this

Evolution and ecology of MHC molecules : From genomics to sexual selection. / Edwards, Scott V.; Hedrick, Philip W.

In: Trends in Ecology and Evolution, Vol. 13, No. 8, 01.08.1998, p. 305-311.

Research output: Contribution to journalArticle

Edwards, Scott V. ; Hedrick, Philip W. / Evolution and ecology of MHC molecules : From genomics to sexual selection. In: Trends in Ecology and Evolution. 1998 ; Vol. 13, No. 8. pp. 305-311.
@article{16ec453520d04c879d72fc19bc3a8edb,
title = "Evolution and ecology of MHC molecules: From genomics to sexual selection",
abstract = "In the past few years the DNA sequence database for molecules of the MHC (major histocompatibility complex) has expanded greatly, yielding a more complete picture of the long-term rates and patterns of evolution of the MHC in vertebrates. Sharing of MHC allelic lineages between long-diverged species (trans-species evolution) has been detected virtually wherever it is sought, but new analyses of linked neutral regions and the complexities of sequence convergence and microrecombination in the peptide binding region challenge traditional phylogenetic analyses. Methods for estimating the intensity of selection on MHC genes suggest that viability is important, but recent studies in natural populations of mammals give inconsistent results concerning mate choice. The complex and interacting roles of microrecombination, parasite-mediated selection and mating preferences for maintaining the extraordinary levels of MHC polymorphism observed are still difficult to evaluate.",
author = "Edwards, {Scott V.} and Hedrick, {Philip W.}",
year = "1998",
month = "8",
day = "1",
doi = "10.1016/S0169-5347(98)01416-5",
language = "English (US)",
volume = "13",
pages = "305--311",
journal = "Trends in Ecology and Evolution",
issn = "0169-5347",
publisher = "Elsevier Limited",
number = "8",

}

TY - JOUR

T1 - Evolution and ecology of MHC molecules

T2 - From genomics to sexual selection

AU - Edwards, Scott V.

AU - Hedrick, Philip W.

PY - 1998/8/1

Y1 - 1998/8/1

N2 - In the past few years the DNA sequence database for molecules of the MHC (major histocompatibility complex) has expanded greatly, yielding a more complete picture of the long-term rates and patterns of evolution of the MHC in vertebrates. Sharing of MHC allelic lineages between long-diverged species (trans-species evolution) has been detected virtually wherever it is sought, but new analyses of linked neutral regions and the complexities of sequence convergence and microrecombination in the peptide binding region challenge traditional phylogenetic analyses. Methods for estimating the intensity of selection on MHC genes suggest that viability is important, but recent studies in natural populations of mammals give inconsistent results concerning mate choice. The complex and interacting roles of microrecombination, parasite-mediated selection and mating preferences for maintaining the extraordinary levels of MHC polymorphism observed are still difficult to evaluate.

AB - In the past few years the DNA sequence database for molecules of the MHC (major histocompatibility complex) has expanded greatly, yielding a more complete picture of the long-term rates and patterns of evolution of the MHC in vertebrates. Sharing of MHC allelic lineages between long-diverged species (trans-species evolution) has been detected virtually wherever it is sought, but new analyses of linked neutral regions and the complexities of sequence convergence and microrecombination in the peptide binding region challenge traditional phylogenetic analyses. Methods for estimating the intensity of selection on MHC genes suggest that viability is important, but recent studies in natural populations of mammals give inconsistent results concerning mate choice. The complex and interacting roles of microrecombination, parasite-mediated selection and mating preferences for maintaining the extraordinary levels of MHC polymorphism observed are still difficult to evaluate.

UR - http://www.scopus.com/inward/record.url?scp=0031851808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031851808&partnerID=8YFLogxK

U2 - 10.1016/S0169-5347(98)01416-5

DO - 10.1016/S0169-5347(98)01416-5

M3 - Article

C2 - 21238318

AN - SCOPUS:0031851808

VL - 13

SP - 305

EP - 311

JO - Trends in Ecology and Evolution

JF - Trends in Ecology and Evolution

SN - 0169-5347

IS - 8

ER -