Evidence, from family studies, for linkage disequilibrium between TGFA and a gene for nonsyndromic cleft lip with or without cleft palate

Hongshu Feng, Russell Sassani, Scott P. Bartlett, Alice Lee, Jacqueline T. Hecht, Susan Malcolm, Robin M. Winter, G. M. Vintiner, Kenneth H. Buetow, David L. Gasser

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39 Scopus citations

Abstract

The inheritance of alleles of the transforming growth factor alpha (TGFA) locus has been studied in families affected with cleft lip with or without cleft palate (CL/P), by using the transmission/disequilibrium test described by Spielman and colleagues. Only heterozygous parents with an affected child can be included in this test, but within such families a significantly greater frequency of C2 alleles were transmitted to affected children than would be expected by chance. There was no evidence that the total number of C2 alleles transmitted to affected and unaffected children differed significantly from random segregation. These data provide evidence from within families that a gene for susceptibility to CL/P is in significant linkage disequilibrium with the C2 allele of the TGFA locus.

Original languageEnglish (US)
Pages (from-to)932-936
Number of pages5
JournalAmerican Journal of Human Genetics
Volume55
Issue number5
StatePublished - Nov 1 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Feng, H., Sassani, R., Bartlett, S. P., Lee, A., Hecht, J. T., Malcolm, S., Winter, R. M., Vintiner, G. M., Buetow, K. H., & Gasser, D. L. (1994). Evidence, from family studies, for linkage disequilibrium between TGFA and a gene for nonsyndromic cleft lip with or without cleft palate. American Journal of Human Genetics, 55(5), 932-936.