Evasion and exploitation of chemokines by viruses

Alshad S. Lalani; Grant McFadden

doi:10.1016/S1359-6101(99)00018-0

Evasion and exploitation of chemokines by viruses

Alshad S. Lalani, Grant McFadden

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Chemokines and chemokine receptors play a critical role in the host defense against viruses by mobilizing leukocytes to sites of infection, injury and inflammation. In order to replicate successfully within their host organisms, viruses have devised novel strategies for exploiting or subverting chemokine networks. This review summarizes various mechanisms that are currently known to be used by viruses for modulating chemokine activities including viral homologs of chemokines and chemokine receptors and soluble viral chemokine binding proteins. Insight into these strategies is providing a wealth of information on viral-host interactions, the function of chemokines in host defense and may help to generate novel anti-chemokine agents for treating against viral diseases or inflammatory disorders.

Original language	English (US)
Pages (from-to)	219-233
Number of pages	15
Journal	Cytokine and Growth Factor Reviews
Volume	10
Issue number	3-4
DOIs	https://doi.org/10.1016/S1359-6101(99)00018-0
State	Published - Sep 1999
Externally published	Yes

Keywords

Chemokine
Herpesvirus
Kaposi's sarcoma
Poxvirus
Viroceptor
Virokine

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
General Biochemistry, Genetics and Molecular Biology

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10.1016/S1359-6101(99)00018-0

Cite this

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title = "Evasion and exploitation of chemokines by viruses",

abstract = "Chemokines and chemokine receptors play a critical role in the host defense against viruses by mobilizing leukocytes to sites of infection, injury and inflammation. In order to replicate successfully within their host organisms, viruses have devised novel strategies for exploiting or subverting chemokine networks. This review summarizes various mechanisms that are currently known to be used by viruses for modulating chemokine activities including viral homologs of chemokines and chemokine receptors and soluble viral chemokine binding proteins. Insight into these strategies is providing a wealth of information on viral-host interactions, the function of chemokines in host defense and may help to generate novel anti-chemokine agents for treating against viral diseases or inflammatory disorders.",

keywords = "Chemokine, Herpesvirus, Kaposi's sarcoma, Poxvirus, Viroceptor, Virokine",

author = "Lalani, {Alshad S.} and Grant McFadden",

note = "Funding Information: We are grateful to Don Ganem for offering critical comments to the manuscript and Chris Boshoff for reproductions of Fig. 2 . The authors work is supported by the Medical Research Council and the National Cancer Institute of Canada (to G.M.) and by a post-doctoral research fellowship from The Howard Hughes Medical Institute (to A.S.L).",

year = "1999",

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doi = "10.1016/S1359-6101(99)00018-0",

language = "English (US)",

volume = "10",

pages = "219--233",

journal = "Cytokine and Growth Factor Reviews",

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number = "3-4",

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T1 - Evasion and exploitation of chemokines by viruses

AU - Lalani, Alshad S.

AU - McFadden, Grant

N1 - Funding Information: We are grateful to Don Ganem for offering critical comments to the manuscript and Chris Boshoff for reproductions of Fig. 2 . The authors work is supported by the Medical Research Council and the National Cancer Institute of Canada (to G.M.) and by a post-doctoral research fellowship from The Howard Hughes Medical Institute (to A.S.L).

PY - 1999/9

Y1 - 1999/9

N2 - Chemokines and chemokine receptors play a critical role in the host defense against viruses by mobilizing leukocytes to sites of infection, injury and inflammation. In order to replicate successfully within their host organisms, viruses have devised novel strategies for exploiting or subverting chemokine networks. This review summarizes various mechanisms that are currently known to be used by viruses for modulating chemokine activities including viral homologs of chemokines and chemokine receptors and soluble viral chemokine binding proteins. Insight into these strategies is providing a wealth of information on viral-host interactions, the function of chemokines in host defense and may help to generate novel anti-chemokine agents for treating against viral diseases or inflammatory disorders.

AB - Chemokines and chemokine receptors play a critical role in the host defense against viruses by mobilizing leukocytes to sites of infection, injury and inflammation. In order to replicate successfully within their host organisms, viruses have devised novel strategies for exploiting or subverting chemokine networks. This review summarizes various mechanisms that are currently known to be used by viruses for modulating chemokine activities including viral homologs of chemokines and chemokine receptors and soluble viral chemokine binding proteins. Insight into these strategies is providing a wealth of information on viral-host interactions, the function of chemokines in host defense and may help to generate novel anti-chemokine agents for treating against viral diseases or inflammatory disorders.

KW - Chemokine

KW - Herpesvirus

KW - Kaposi's sarcoma

KW - Poxvirus

KW - Viroceptor

KW - Virokine

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DO - 10.1016/S1359-6101(99)00018-0

M3 - Review article

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AN - SCOPUS:0033192434

SN - 1359-6101

VL - 10

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JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 3-4

ER -

Evasion and exploitation of chemokines by viruses

Abstract

Keywords

ASJC Scopus subject areas

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