Evasion and exploitation of chemokines by viruses

Alshad S. Lalani, Grant McFadden

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Chemokines and chemokine receptors play a critical role in the host defense against viruses by mobilizing leukocytes to sites of infection, injury and inflammation. In order to replicate successfully within their host organisms, viruses have devised novel strategies for exploiting or subverting chemokine networks. This review summarizes various mechanisms that are currently known to be used by viruses for modulating chemokine activities including viral homologs of chemokines and chemokine receptors and soluble viral chemokine binding proteins. Insight into these strategies is providing a wealth of information on viral-host interactions, the function of chemokines in host defense and may help to generate novel anti-chemokine agents for treating against viral diseases or inflammatory disorders.

Original languageEnglish (US)
Pages (from-to)219-233
Number of pages15
JournalCytokine and Growth Factor Reviews
Volume10
Issue number3-4
DOIs
StatePublished - Sep 1 1999
Externally publishedYes

Keywords

  • Chemokine
  • Herpesvirus
  • Kaposi's sarcoma
  • Poxvirus
  • Viroceptor
  • Virokine

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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